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Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine
Aggregate ( IF 13.9 ) Pub Date : 2021-09-14 , DOI: 10.1002/agt2.120
Yangmeihui Song _{1,

2} , Wenyu Song _{1,

2} , Xiaoli Lan _{1,

2} , Weibo Cai ₃ , Dawei Jiang _{1,

2}

Affiliation

Spherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by Mirkin and coworkers in 1996, it has created a significant interest by offering new possibilities in the field of gene and drug delivery. The controlled aggregation of oligonucleotides on the surface of organic/inorganic nanoparticles improves the delivery of genes and nucleic acid–based drugs and alters and regulates the biological profiles of the nanoparticle core within living organisms. Here in this review, we present an overview of the recent progress of SNAs that has speeded up their biomedical application and their potential transition to clinical use. We start with introducing the concept and characteristics of SNAs as drug/gene delivery systems and highlight recent efforts of bioengineering SNA by imaging and treatmenting various diseases. Finally, we discuss potential challenges and opportunities of SNAs, their ongoing clinical trials, and future translation, and how they may affect the current landscape of clinical practices. We hope that this review will update our current understanding of SNA, organized oligonucleotide aggregates, for disease diagnosis and treatment.

中文翻译：

球形核酸：作为多功能纳米药物的有组织的核苷酸聚集体

球形核酸 (SNA) 由纳米颗粒核心和一层密集排列的寡核苷酸壳组成。在 1996 年 Mirkin 及其同事首次报告 SNA 后，它通过在基因和药物递送领域提供新的可能性而引起了极大的兴趣。寡核苷酸在有机/无机纳米粒子表面的受控聚集改善了基因和基于核酸的药物的传递，并改变和调节了生物体内纳米粒子核心的生物学特征。在这篇综述中，我们概述了 SNA 的最新进展，这些进展加速了它们的生物医学应用以及它们向临床应用的潜在过渡。我们首先介绍 SNA 作为药物/基因传递系统的概念和特征，并重点介绍生物工程 SNA 通过成像和治疗各种疾病的近期努力。最后，我们讨论了 SNA 的潜在挑战和机遇、正在进行的临床试验和未来的翻译，以及它们如何影响当前的临床实践格局。我们希望这篇综述能更新我们目前对 SNA、有组织的寡核苷酸聚集体、用于疾病诊断和治疗的理解。

更新日期：2021-09-14

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