Journal of Fluorescence ( IF 2.6 ) Pub Date : 2021-09-14 , DOI: 10.1007/s10895-021-02805-1 Rahman Hallaj 1, 2 , Zahra Hosseinchi 1
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Abstract
This work focuses on the synthesis of novel modified core–shell CdTe/CdS quantum dots (QDs) and develops as a fluorescence sensor for glucose determination. The (E)-2,2'-(4,4'-dioxo-2,2'-dithioxo-2H,2'H-[5,5'-bithiazolylidene]-3,3'(4H,4'H)-diyl)bis(3- mercaptopropanoic acid) (DTM) as a new derivative of thiazolidine was synthesized and characterized and used to surface-modification of CdTe/CdS QDs. DTM-capped CdTe/CdS QDs used to immobilization of glucose oxidase (GOD). The intensity fluorescence emission of the CdSe/CdS-DTM/GOD is highly sensitive to the concentration of H2O2 as a byproduct of the catalytic oxidation of glucose. The experimental results showed that the quenched fluorescence was proportional to the glucose concentration within the range of 10 nM—0.32 μM under optimized experimental conditions. The limit of detection of this system was found to be 4.3 nM. Compared with most of the existing methods, this newly developed system possesses many advantages, including simplicity, low cost, and good sensitivity.
Graphical abstract
中文翻译：
生物相容性噻唑烷衍生物表面修饰的胶体 CdTe/CdS 量子点作为固定葡萄糖氧化酶的有希望的平台：在葡萄糖荧光传感中的应用
摘要
这项工作的重点是新型改性核壳 CdTe/CdS 量子点 (QD) 的合成，并将其开发为用于葡萄糖测定的荧光传感器。(E)-2,2'-(4,4'-dioxo-2,2'-dithioxo-2H,2'H-[5,5'-bithiazolylidene]-3,3'(4H,4'H )-diyl)bis(3-mercaptopropanoic acid) (DTM) 作为噻唑烷的新衍生物被合成和表征，并用于 CdTe/CdS 量子点的表面修饰。DTM 封端的 CdTe/CdS QD 用于固定葡萄糖氧化酶 (GOD)。CdSe/CdS-DTM/GOD 的强度荧光发射对 H 2 O 2的浓度高度敏感作为葡萄糖催化氧化的副产物。实验结果表明，在优化的实验条件下，在10 nM—0.32 μM范围内，荧光猝灭与葡萄糖浓度成正比。发现该系统的检测限为 4.3 nM。与大多数现有方法相比，这种新开发的系统具有许多优点，包括简单、低成本和良好的灵敏度。
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