The need to overcome ever-increasing cases of antifungal resistance and circumvent side effects and drug interactions related to currently available drugs has impelled the demand to expedite the drug discovery and the development of novel antifungals. 1,4-disubstituted 1,2,3-triazole has gained tremendous interest in the last two decades mainly because of its ease of synthesis via copper( I)-catalyzed azide-alkyne cycloaddition (CuAAC) and its broad spectrum of chemotherapeutic potential. 1,2,3-Triazole is an excellent pharmacophore that has been used as a bioisostere for obtaining libraries of new medicinally important scaffolds. The present review focuses on the recent advances (2016-2021) in 1,2,3-triazole derivatives obtained by CuAAC as potential antifungal agents that may facilitate the triazole-based antifungal development process.

中文翻译：

---

1H-1,2,3-三唑作为潜在抗真菌剂的最新进展。

克服不断增加的抗真菌药物耐药性和规避与当前可用药物相关的副作用和药物相互作用的需求推动了加快药物发现和开发新型抗真菌药物的需求。1,4-二取代的 1,2,3-三唑在过去的二十年中引起了极大的兴趣，主要是因为它易于通过铜 (I) 催化的叠氮化物-炔烃环加成 (CuAAC) 合成及其广泛的化学治疗潜力。1,2,3-三唑是一种出色的药效团，已被用作生物等排体，用于获得新的药用重要支架文库。本综述重点介绍了由 CuAAC 获得的 1,2,3-三唑衍生物作为潜在抗真菌剂的最新进展（2016-2021 年），这些衍生物可能有助于三唑类抗真菌药物的开发过程。