A Water-Soluble Peptoid Chelator that Can Remove Cu2+ from Amyloid-β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Water-Soluble Peptoid Chelator that Can Remove Cu2+ from Amyloid-β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-12 , DOI: 10.1002/anie.202109758
Anastasia E Behar ₁ , Laurent Sabater _{2,

3} , Maria Baskin ₁ , Christelle Hureau _{2,

3} , Galia Maayan ₁

Affiliation

Cu-chelation from amyloid-β (Aβ) peptide complexes is a known approach towards the development of therapeutics for Alzheimer's disease (AD), the most common form of dementia. Herein we describe a water-soluble peptidomimetic chelator that removes Cu from Cu–Aβ in the presence of Zn, forming the thermodynamically stable Cu–chelator complex, and by this enables the inhibition of ROS production in a reducing environment at physiological pH.

中文翻译：

一种水溶性类肽螯合剂，可从淀粉样蛋白 β 肽中去除 Cu2+ 并阻止与阿尔茨海默病相关的活性氧物种的形成

来自淀粉样蛋白-β (Aβ) 肽复合物的 Cu 螯合是开发阿尔茨海默病 (AD)（最常见的痴呆症）疗法的一种已知方法。在本文中，我们描述了一种水溶性拟肽螯合剂，它在存在 Zn 的情况下从 Cu-Aβ 中去除 Cu，形成热力学稳定的 Cu-螯合剂复合物，从而能够在生理 pH 值的还原环境中抑制 ROS 的产生。

更新日期：2021-10-29

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南