Synthesis and Functionalization of Imidazo[1,2-b]Pyridazine by Means of Metal-Catalyzed Cross-Coupling Reactions,ChemistrySelect

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Synthesis and Functionalization of Imidazo[1,2-b]Pyridazine by Means of Metal-Catalyzed Cross-Coupling Reactions
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-08 , DOI: 10.1002/slct.202101636
Ahmed El Akkaoui ₁ , Jamal Koubachi ₂ , Gérald Guillaumet _{3,

4} , Saïd El Kazzouli ₄

Affiliation

This review surveys the recent developments in organometallic-chemistry-based methods for the preparation of imidazo[1,2-b]pyridazines by cyclization as well as their functionalization by means of cross-coupling reactions such as Sonogashira, Heck, Negishi, Suzuki-Miyaura, Kumada and Stille. In addition, the advances made on the C−H activation of imidazo[1,2-b]pyridazines using C-arylation, C-benzylation and C-alkylation are also reviewed. Furthermore, the recent reports on the N-arylation of this heterocyclic system are discussed and highlighted. The sequential couplings as well as the one-pot functionalization of two different positions on the imidazo[1,2-b]pyridazine systems are also reviewed. Procedures in which metal-based catalysis is not involved in the functionalization of imidazo[1,2-b]pyridazines are not included in this review.

中文翻译：

咪唑并[1,2-b]哒嗪的金属催化交叉偶联反应合成与功能化

本综述调查了基于有机金属化学的方法的最新进展，用于通过环化制备咪唑并 [1,2- b ] 哒嗪以及通过交叉偶联反应将其官能化，例如 Sonogashira、Heck、Negishi、Suzuki-宫浦、熊田和斯蒂尔。此外，还综述了使用C-芳基化、C-苄基化和C-烷基化对咪唑并[1,2- b ]哒嗪进行C-H活化的研究进展。此外，讨论并强调了最近关于该杂环系统的N-芳基化的报道。咪唑[1,2- b]上两个不同位置的顺序偶联以及一锅法功能化]哒嗪系统也进行了审查。本综述不包括金属基催化不参与咪唑并[1,2- b ]哒嗪官能化的程序。

更新日期：2021-09-09

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