Picolyl and benzyl linked biphenyl NHC ligands L¹H₂Br₂to L⁴H₂Br₂(L1-L4) and their silver-N-heterocyclic carbene complexes [AgL2]PF₆(1), [AgL3]PF₆(2), and [AgL4]PF₆(3) were synthesized and characterized. Sigma donating properties of the NHC ligands were calculated by proton-coupled ¹³C-NMR spectroscopy. Silver-N-heterocyclic carbene complexes were synthesized via in situ deprotonation of azolium salts with silver(I) oxide under the light exclusion. One of the silver complexes, [AgL3]PF₆(2), was confirmed by a single crystal XRD. All the ligands and silver-N-heterocyclic carbene complexes were investigated for antimicrobial activity against the bacterial strains grown from human clinical isolates. The NHC ligands and Ag-NHC complexes showed better antimicrobial activity than the reported phenyl-substituted NHC precursors and their Silver-NHC complexes against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa bacterial strains.

Picolyl 和苄基连接的联苯 NHC 配体 L ¹ H ₂ Br ₂到 L ⁴ H ₂ Br ₂ ( L1 - L4 ) 及其银-N-杂环卡宾配合物 [AgL2]PF ₆ ( 1) , [AgL3]PF ₆ ( 2) ) 和 [AgL4]PF ₆ ( 3 ) 被合成和表征。通过质子耦合¹³ C-NMR 光谱计算 NHC 配体的 Sigma 捐赠特性。银-N-杂环卡宾配合物的原位合成在光排除下用氧化银（I）对唑盐进行去质子化。银络合物之一，[AgL3]PF ₆ ( 2 )，由单晶XRD 证实。研究了所有配体和银-N-杂环卡宾复合物对从人类临床分离株中生长的细菌菌株的抗微生物活性。NHC 配体和 Ag-NHC 复合物比报道的苯基取代 NHC 前体及其银-NHC 复合物对革兰氏阳性金黄色葡萄球菌和革兰氏阴性铜绿假单胞菌菌株显示出更好的抗菌活性。