作为人工软骨候选物的多层水凝胶的制备和表征,ACS Applied Polymer Materials

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作为人工软骨候选物的多层水凝胶的制备和表征
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2021-09-07 , DOI: 10.1021/acsapm.1c00807
Xinyue Zhang ₁ , Zichen Lou ₂ , Xuehui Yang ₃ , Qin Chen ₂ , Kai Chen ₂ , Cunao Feng ₂ , Jianwei Qi ₂ , Yong Luo ₂ , Dekun Zhang ₂

Affiliation

骨骼和软骨是高度组织的组织，具有梯度分层，使软骨具有良好的润滑和承载能力。受天然关节软骨梯度结构的启发，选择 PVA-HA 和 PVA-HA-PAA 复合水凝胶通过物理结合制备分层仿生软骨材料。下部 PVA-HA 复合水凝胶和上部 PVA-HA-PAA 复合水凝胶分别为仿生软骨材料提供优异的润滑和承载能力。此外，通过在氧化酯化后将多层仿生软骨水凝胶移植到 UHMWPE 上来构建软骨 - 骨材料，以模拟骨 - 软骨分层结构。多层软骨材料具有优异的拉伸断裂性能（拉伸强度38.90±1.5MPa，545±32%，拉伸模量 1.73 ± 0.06 MPa）、压缩性能（压缩强度 3.1 ± 0.15 MPa，压缩模量 4.47 ± 0.2 MPa）、热稳定性、摩擦性能（摩擦系数 0.035 ± 0.0028）和生物相容性。因此，仿生软骨材料具有高强度、低摩擦的梯度分层结构，显着提高了人工关节的稳定性和寿命。

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Fabrication and Characterization of a Multilayer Hydrogel as a Candidate for Artificial Cartilage

Bone and cartilage are highly organized tissues with gradient layered, which makes cartilage have good lubrication and bearing capacity. Inspired by the gradient structure of natural articular cartilage, the PVA–HA and PVA–HA–PAA composite hydrogels were selected to prepare a hierarchical bionic cartilage material by physical bonding. The lower PVA–HA composite hydrogel and the upper PVA–HA–PAA composite hydrogel provide excellent lubrication and loading-bearing ability to bionic cartilage materials, respectively. Furthermore, the cartilage–bone material was constructed by grafting the multilayer bionic cartilage hydrogel onto the UHMWPE after oxidation esterification to simulate the bone–cartilage hierarchical structure. The multilayer cartilage material has excellent tensile fracture properties (tensile strength 38.90 ± 1.5 MPa, 545 ± 32%, tensile modulus 1.73 ± 0.06 MPa), compression properties (compressive strength 3.1 ± 0.15 MPa, compressive modulus 4.47 ± 0.2 MPa), thermostability, friction properties (friction coefficient 0.035 ± 0.0028), and biocompatibility. Thus, the bionic cartilage material has a gradient-layered structure with high strength and low friction, which significantly improves the stability and life of artificial joints.

更新日期：2021-10-08

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