Abstract

This work represents a simple and efficient synthesis of novel 2-amino-N'-(9H-fluoren-9-ylidene)-hexahydroquinoline-3-carbohydrazide derivatives via the multi-component reaction of diverse anilines, dimedone, 9-fluorenone, cyanoacetohydrazide, and aromatic aldehydes in the presence of piperidine as a catalyst. The proposed approach has some advantages as good yields, green medium, short reaction times, simple work-up, and purification process with no chromatographic technique compared with other methods.

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中文翻译：

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2-氨基-N'-(9H-Fluoren-9-Ylidene)-Hexahydroquinoline-3-Carbohydrazide 衍生物的简单合成

摘要

这项工作代表了一种通过多种苯胺、二甲酮、9-芴酮的多组分反应简单有效地合成新型 2-氨基-N' -(9 H -fluoren-9-ylidene)-hexahydroquinoline-3-carbohydrazide 衍生物的方法，在哌啶作为催化剂存在下，氰基乙酰肼和芳香醛。与其他方法相比，该方法具有收率高、绿色介质、反应时间短、后处理简单、纯化过程无需色谱技术等优点。

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