Dermatological formulations can enable a more efficient therapy by directly delivering the active ingredient to the action site. Photodynamic therapy is a promising technique to eliminate the microorganism in wounds. The present work aims to obtention a dermatological bioadhesive and stimuli-responsive platform that efficiently solubilizes aluminum phthalocyanine hydroxide (AlPcOH) photosensitizer. A better formulation for dermatological application was obtained after evaluation of the formulation polymeric composition and mechanical characterization. Ex-vivo permeation and complete rheological assays were carried out. The photodynamic potential of AlPcOH was evaluated quantitatively and qualitatively. AlPcOH was shown to be incorporated mostly in monomeric form when subjected to the solid dispersion method. Satisfactory results were achieved for the formulation composed of 0.05, 20, and 0.20 % w/w of AlPcOH, F127 and Carbopol. This formulation was easily administered and presented adequate retention at the application site. Furthermore, the system showed a gelation temperature of 29.1 °C, ensuring the preparation, filling, and administration in the bodýs temperature. The nanostructured thermo-responsive platform promoted AlPcOH skin permeation effects and demonstrated a high capacity to generate reactive oxygen species (Ф_Δ¹O₂ for AlPcOH of 0.68 in ethanol). All the information provided in this study supports the potential of the AlPcOH-containing platform designed to treat wounds aggravated by microbial infections. It suggests future in vitro and in vivo applications of the platform developed.

皮肤病制剂可以通过将活性成分直接输送到作用部位来实现更有效的治疗。光动力疗法是一种很有前途的技术，可以消除伤口中的微生物。目前的工作旨在获得一种皮肤病生物粘附和刺激响应平台，可有效溶解铝酞菁氢氧化物 (AlPcOH) 光敏剂。在对配方聚合物组成和机械特性进行评估后，获得了用于皮肤病学应用的更好配方。离体进行了渗透和完整的流变分析。定量和定性地评估了 AlPcOH 的光动力势。当采用固体分散法时，显示出 AlPcOH 主要以单体形式掺入。由 0.05、20 和 0.20 % w/w 的 AlPcOH、F127 和 Carbopol 组成的配方获得了令人满意的结果。该制剂易于给药并且在应用部位具有足够的保留。此外，该系统的凝胶温度为 29.1 °C，确保在身体温度下进行制备、填充和给药。纳米结构的热响应平台促进了 AlPcOH 皮肤渗透效应，并表现出产生活性氧的能力（Ф _Δ ¹ O ₂对于乙醇中 0.68 的 AlPcOH）。本研究中提供的所有信息都支持含 AlPcOH 平台的潜力，该平台旨在治疗因微生物感染而加重的伤口。它表明该平台未来的体外和体内应用。