Monodispersed MOF-808 Nanocrystals Synthesized via a Scalable Room-Temperature Approach for Efficient Heterogeneous Peptide Bond Hydrolysis,Chemistry of Materials

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Monodispersed MOF-808 Nanocrystals Synthesized via a Scalable Room-Temperature Approach for Efficient Heterogeneous Peptide Bond Hydrolysis
Chemistry of Materials ( IF 7.2 ) Pub Date : 2021-08-30 , DOI: 10.1021/acs.chemmater.1c02174
Shan Dai ₁ , Charlotte Simms ₂ , Iurii Dovgaliuk ₁ , Gilles Patriarche ₃ , Antoine Tissot ₁ , Tatjana N. Parac-Vogt ₂ , Christian Serre ₁

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Zr(IV)-based metal–organic frameworks (MOFs) such as the Zr(IV) trimesate MOF-808 are promising materials for catalytic applications. In this work, we report an aqueous solution-based room-temperature strategy to produce well-defined monodispersed MOF-808 nanocrystals down to 35 nm with a high space-time yield, up to 2516 kg/m³/day, and excellent crystallinity and porosity. The resulting nanocrystals show remarkable colloidal dispersion during 1 day in a wide range of nanoparticle concentrations. As a result, 35 nm MOF-808 colloidal-level nanocrystals exhibit the highest rate of selective peptide bond and protein hydrolysis among the reported Zr(IV)-based MOFs. This result may open new opportunities for highly efficient peptide or protein hydrolysis using scalable nanocatalysts.

中文翻译：

通过可扩展的室温方法合成的单分散 MOF-808 纳米晶体用于有效的多相肽键水解

基于 Zr(IV) 的金属有机骨架 (MOF)，例如 Zr(IV) 均苯三甲酸酯 MOF-808，是用于催化应用的有前途的材料。在这项工作中，我们报告了一种基于水溶液的室温策略，以生产低至 35 nm 的明确单分散 MOF-808 纳米晶体，具有高时空产率，高达 2516 kg/m ³ /天，以及优异的结晶度和孔隙率。得到的纳米晶体在 1 天内在广泛的纳米颗粒浓度范围内显示出显着的胶体分散。因此，在报道的基于 Zr(IV) 的 MOF 中，35 nm MOF-808 胶体级纳米晶体表现出最高的选择性肽键和蛋白质水解率。这一结果可能为使用可扩展纳米催化剂的高效肽或蛋白质水解开辟新的机会。

更新日期：2021-09-14

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