1,2,4-Triazoles and 1,3,4-oxadiazoles are prevalent moieties in pharmaceutical agents, yet fused [1,2,4]triazolo[3,4-b][1,3,4]oxadiazoles are surprisingly under-represented for both synthesis and biological application. We report a rapid, two-step synthesis of [1,2,4]triazolo[3,4-b][1,3,4]oxadiazoles from commercial 4-amino-1,2,4-triazoles that is highlighted by a microwave accelerated intramolecular cyclization to generate the fused ring system. Our efforts to optimize reaction conditions and elucidate reaction mechanism are also described.

中文翻译：

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从4-酰基氨基-1,2,4-三唑快速微波加速合成[1,2,4]三唑[3,4-b] [1,3,4]恶二唑

1,2,4-三唑和1,3,4-恶二唑是药剂中的主要部分，但令人惊讶的是，稠合的[1,2,4]三唑[3,4-b] [1,3,4]恶二唑在-代表用于合成和生物学应用。我们报告了快速，两步合成[1,2,4]三唑[3,4-b] [1,3,4]恶二唑从商业4-氨基-1,2,4-三唑的突出显示微波加速了分子内环化反应以生成稠环系统。还描述了我们优化反应条件和阐明反应机理的努力。