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Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer
Bioengineered ( IF 4.2 ) Pub Date : 2021-08-26 , DOI: 10.1080/21655979.2021.1960768
Yongsheng Meng 1, 2 , Chenyan Long 3 , Xiaoliang Huang 1, 2 , Lihaoyun Huang 1, 2 , Lixian Liao 1, 2 , Weizhong Tang 1, 2 , Jungang Liu 1, 2
Affiliation  

ABSTRACT

Systemic inflammatory response (SIRS) can be used as a potential prognostic marker in patients with colorectal cancer (CRC). The purpose of this study was to examine the predictive role of the C-reactive protein (CRP)-lymphocyte ratio (CLR) in the prognosis of CRC. We retrospectively analyzed the data of CRC patients who underwent surgery from 2004 to 2019. The clinicopathological characteristics and follow-up records were analyzed. According to a cutoff value of CLR, the patients were divided into the high and low groups. Kaplan–Meier curves and Cox proportional hazards regression model were applied to assess the overall survival (OS). Clinicopathological characteristics analysis showed that gender, age, BMI, lymphocyte count, tumor location, left- and right-sided CRC, differentiation, T stage, M stage, TNM stage, carcinoembryonic antigen (CEA), CLR, CRP, and microsatellite status were found to differ significantly between the high and low CLR groups. Kaplan–Meier curves revealed that the high CLR group had a shorter OS, and the elderly or right-sided CRC patients faced a worse prognosis. Multivariate analysis suggested that age (hazard ratio [HR]:1.011, P = 0.003), differentiation (HR:1.331, P = 0.000), TNM stage (HR:2.425, P = 0.000), CEA (HR:1.001, P = 0.025), CLR (HR:1.261, P = 0.014) were significant independent prognostic factors for OS. Subgroup analysis demonstrated that females or patients not receiving postoperative adjuvant chemotherapy with high CLR might suffer a worse prognosis. Overall, CLR can be applied as a promising prognostic marker in CRC patients and has great potential in guiding clinical work.



中文翻译:

C反应蛋白-淋巴细胞比值在结直肠癌中的预后作用及临床意义

摘要

全身炎症反应 (SIRS) 可用作结直肠癌 (CRC) 患者的潜在预后标志物。本研究的目的是检验 C 反应蛋白 (CRP)-淋巴细胞比值 (CLR) 在 CRC 预后中的预测作用。回顾性分析2004-2019年接受手术的CRC患者资料,分析临床病理特征及随访记录。根据CLR的临界值,将患者分为高组和低组。应用 Kaplan-Meier 曲线和 Cox 比例风险回归模型评估总生存期 (OS)。临床病理特征分析显示性别、年龄、BMI、淋巴细胞计数、肿瘤部位、左右侧CRC、分化程度、T分期、M分期、TNM分期、癌胚抗原(CEA)、发现 CLR、CRP 和微卫星状态在高 CLR 组和低 CLR 组之间存在显着差异。Kaplan-Meier 曲线显示,高 CLR 组的 OS 较短,而老年或右侧 CRC 患者的预后较差。多变量分析表明,年龄(风险比 [HR]:1.011,P = 0.003)、分化 (HR:1.331, P = 0.000)、TNM 分期 (HR:2.425, P = 0.000)、CEA (HR:1.001, P = 0.025)、CLR (HR:1.261, P = 0.014) OS 的重要独立预后因素。亚组分析表明,高 CLR 的女性或未接受术后辅助化疗的患者预后可能更差。总体而言,CLR 可作为一种有前途的 CRC 患者预后标志物,在指导临床工作方面具有巨大潜力。

更新日期:2021-08-27
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