Here we describe the preparation of 2-(4-((1H-benzo[d]imidazol-2-yl)thio)-benzylidene)-hydrazine-1-carbothioamide in two steps. In the first step, 1,3-dihydro-2H-1,3-benzimidazole-2-thione was reacted with 4-fluorobenzaldehyde in DMSO to get 4-[(1H-benzimidazol-2-yl)sulfanyl]benzaldehyde in high yield. The reaction of the obtained aldehyde with thiosemicarbazide in ethanol at reflux temperature yielded 2-({4-[(1H-benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide. The structure of the synthesized compounds was established by NMR spectroscopy (¹H, ¹³C), mass spectrometry, and infrared spectroscopy.

中文翻译：

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4-[(1H-Benzimidazol-2-yl)sulfanyl]苯甲醛和2-({4-[(1H-Benzimidazol-2-yl)sulfanyl]苯基}亚甲基)hydrazine-1-carbothioamide的合成

在这里，我们描述了 2-(4-((1 H- benzo[d]imidazol-2-yl)thio)-benzlidene)-hydrazine-1-carbothioamide 分两步的制备。第一步，1,3-二氢-2H-1,3-苯并咪唑-2-硫酮在DMSO中与4-氟苯甲醛反应，得到4-[(1 H-苯并咪唑-2-基)硫烷基]苯甲醛。屈服。所得醛与氨基硫脲在乙醇中在回流温度下反应生成2-({4-[(1 H-苯并咪唑-2-基)硫烷基]苯基}亚甲基)肼-1-碳硫酰胺。合成化合物的结构通过核磁共振光谱( ¹ H, ¹³ C)、质谱和红外光谱确定。