Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-08-26 , DOI: 10.1007/s00706-021-02834-3 Majid M. Heravi 1 , Vahideh Zadsirjan 1 , Masoume Malmir 1 , Leila Mohammadi 1
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Carbon–nitrogen cross-coupling reaction is an imperative and vital conversion in organic synthesis since one of its products, arylamines, are key frameworks in several natural products, pharmaceuticals, and other biologically active compounds. For the development of such important C–N coupling reaction, Buchwald and Hartwig made noteworthy contributions by presenting a plethora of ligands in addition to the conventional Pd and Cu catalysts. In this review, we try to update our previous review, covering the recent progresses in applications of Buchwald–Hartwig reaction in organic reactions, in the synthesis of heterocyclic compounds and total synthesis of natural products. This review covers this important advancement from 2018 till date.
Graphic abstract
中文翻译：
Buchwald-Hartwig 反应：更新
碳氮交叉偶联反应是有机合成中必不可少的重要转化，因为其产物之一芳胺是几种天然产物、药物和其他生物活性化合物的关键框架。对于这种重要的 C-N 偶联反应的发展，Buchwald 和 Hartwig 除了传统的 Pd 和 Cu 催化剂外，还提出了大量的配体，做出了值得注意的贡献。在这篇综述中，我们尝试更新我们之前的综述，涵盖了 Buchwald-Hartwig 反应在有机反应、杂环化合物合成和天然产物全合成中的应用的最新进展。本次审查涵盖了 2018 年至今的这一重要进展。
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