Targeted Delivery of Anesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anesthesia,Advanced Functional Materials

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Targeted Delivery of Anesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anesthesia
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-08-21 , DOI: 10.1002/adfm.202105686
Razina Z. Seeni _{1,

2} , Mengjia Zheng ₃ , Daniel Chin Shiuan Lio ₄ , Christian Wiraja ₄ , Mohammad Firdaus Bin Mohd Yusoff ₄ , William Teck Yeow Koh _{1,

2} , Yuchun Liu _{1,

2} , Bee Tin Goh _{1,

2,

5} , Chenjie Xu _{1,

3}

Affiliation

Pain management during dental procedures is a cornerstone for successful daily practice. In current practice, the traditional needle and syringe injection is used to administer local anesthesia. However, the appearance of long needles and the pain associated with it often leads to dental anxiety deterring timely interventions. Microneedles (MNs) have emerged as a minimally invasive alternative to hypodermic needles and shown to be effective in transdermal drug delivery applications. In this article, the potential use of MNs for local anesthesia delivery in dentistry is explored. The development of a novel conductive MN array that can be used in combination with iontophoresis technique to achieve drug penetration through the oral mucosa and the underlying bone tissue is presented. The conductive MN array plays a dual-role, creating micro-conduits and lowering the resistance of the oral mucosa. The reduced tissue resistance further enhances the application of a low-voltage current that is able to direct and accelerate the drug molecules to target the sensory nerves supplying teeth. The successful delivery of lidocaine using this new strategy in a clinically relevant rabbit incisor model is shown to be as effective as the current gold standard.

中文翻译：

使用导电微针增强离子电渗疗法将麻醉剂靶向递送至骨组织，用于无痛牙科麻醉

牙科手术期间的疼痛管理是成功日常实践的基石。在目前的实践中，使用传统的针头和注射器注射进行局部麻醉。然而，长针的出现和与之相关的疼痛通常会导致牙科焦虑，从而阻碍及时干预。微针 (MNs) 已成为皮下注射针的微创替代品，并显示在透皮给药应用中有效。在本文中，探讨了 MN 在牙科局部麻醉中的潜在用途。介绍了一种新型导电 MN 阵列的开发，该阵列可与离子电渗技术结合使用，以实现药物通过口腔黏膜和下方骨组织的渗透。导电 MN 阵列具有双重作用，形成微导管，降低口腔黏膜阻力。降低的组织电阻进一步增强了低压电流的应用，该电流能够引导和加速药物分子以靶向供应牙齿的感觉神经。在临床相关的兔门牙模型中使用这种新策略成功输送利多卡因被证明与当前的金标准一样有效。

更新日期：2021-08-21

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