Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor
ACS Omega ( IF 3.7 ) Pub Date : 2021-08-21 , DOI: 10.1021/acsomega.1c02903 Zhiyuan Meng 1 , Yichao Liu 2 , Kexiang Xu 1 , Xing Sun 1 , Qingwen Yu 1 , Zhongqing Wu 1 , Zheng Zhao 1
ACS Omega ( IF 3.7 ) Pub Date : 2021-08-21 , DOI: 10.1021/acsomega.1c02903 Zhiyuan Meng 1 , Yichao Liu 2 , Kexiang Xu 1 , Xing Sun 1 , Qingwen Yu 1 , Zhongqing Wu 1 , Zheng Zhao 1
Affiliation
|
The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection of osteosarcoma is still a challenge in the clinic. Combination therapy based on a localized drug-delivery system shows great promise in the treatment of osteosarcoma. Herein, bifunctional polydopamine (PDA)-modified curcumin (CM)-loaded silk fibroin (SF) composite (SF/CM-PDA) nanofibrous scaffolds, which combined photothermal therapy with chemotherapy to synergistically enhance osteosarcoma therapy, were prepared by PDA coating of the SF/CM nanofibrous scaffolds fabricated by supercritical carbon dioxide (SC-CO2) technology. The PDA coating improved hydrophilicity and mechanical strength of the SF/CM scaffolds. The SF/CM-PDA scaffolds present good photothermal conversion capacity and excellent photostability. The low pH and near-infrared (NIR) irradiation could effectively accelerate release of CM in the SF/CM-PDA scaffolds. The in vitro anticancer results indicated that the biocompatible SF/CM-PDA scaffolds had a long-term, stable, and superior anticancer effect compared to pure CM. Furthermore, the SF/CM-PDA scaffolds significantly increased the growth inhibition of osteosarcoma MG-63 cells under NIR irradiation (808 nm and 1.3 W/cm2). Besides, the SF/CM-PDA scaffolds could enhance osteoblast MC3T3-E1 cell proliferation in vitro when the mass ratio of CM was 0.05–0.5%. This work has therefore demonstrated that the bifunctional SF/CM-PDA scaffolds provide a competitive strategy for local osteosarcoma therapy and bone regeneration.
中文翻译：
仿生聚多巴胺修饰的丝素/姜黄素纳米纤维支架用于骨肿瘤的化学光热治疗
同时治疗骨肉瘤手术切除引起的肿瘤复发和骨缺损仍然是临床上的一个挑战。基于局部给药系统的联合疗法在骨肉瘤的治疗中显示出巨大的前景。在此，通过PDA涂层制备了双功能聚多巴胺（PDA）修饰的姜黄素（CM）负载丝素蛋白（SF）复合（SF/CM-PDA）纳米纤维支架，将光热疗法与化学疗法相结合，协同增强骨肉瘤的治疗效果。 SF/CM 纳米纤维支架由超临界二氧化碳 (SC-CO 2） 技术。PDA 涂层提高了 SF/CM 支架的亲水性和机械强度。SF/CM-PDA 支架具有良好的光热转换能力和优异的光稳定性。低 pH 值和近红外 (NIR) 照射可以有效加速 SF/CM-PDA 支架中 CM 的释放。体外抗癌结果表明，与纯CM相比，生物相容性SF/CM-PDA支架具有长期、稳定和优越的抗癌作用。此外，SF/CM-PDA 支架显着增加了骨肉瘤 MG-63 细胞在近红外辐射（808 nm 和 1.3 W/cm 2）。此外，当CM的质量比为0.05-0.5%时，SF/CM-PDA支架可以增强体外成骨细胞MC3T3-E1细胞的增殖。因此，这项工作表明，双功能 SF/CM-PDA 支架为局部骨肉瘤治疗和骨再生提供了一种竞争策略。
更新日期：2021-08-31
中文翻译：
仿生聚多巴胺修饰的丝素/姜黄素纳米纤维支架用于骨肿瘤的化学光热治疗
同时治疗骨肉瘤手术切除引起的肿瘤复发和骨缺损仍然是临床上的一个挑战。基于局部给药系统的联合疗法在骨肉瘤的治疗中显示出巨大的前景。在此，通过PDA涂层制备了双功能聚多巴胺（PDA）修饰的姜黄素（CM）负载丝素蛋白（SF）复合（SF/CM-PDA）纳米纤维支架，将光热疗法与化学疗法相结合，协同增强骨肉瘤的治疗效果。 SF/CM 纳米纤维支架由超临界二氧化碳 (SC-CO 2） 技术。PDA 涂层提高了 SF/CM 支架的亲水性和机械强度。SF/CM-PDA 支架具有良好的光热转换能力和优异的光稳定性。低 pH 值和近红外 (NIR) 照射可以有效加速 SF/CM-PDA 支架中 CM 的释放。体外抗癌结果表明，与纯CM相比，生物相容性SF/CM-PDA支架具有长期、稳定和优越的抗癌作用。此外，SF/CM-PDA 支架显着增加了骨肉瘤 MG-63 细胞在近红外辐射（808 nm 和 1.3 W/cm 2）。此外，当CM的质量比为0.05-0.5%时，SF/CM-PDA支架可以增强体外成骨细胞MC3T3-E1细胞的增殖。因此，这项工作表明，双功能 SF/CM-PDA 支架为局部骨肉瘤治疗和骨再生提供了一种竞争策略。
京公网安备 11010802027423号