An efficient domino strategy for synthesis of 3-substituted 4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine derivatives in water,Molecular Diversity

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An efficient domino strategy for synthesis of 3-substituted 4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine derivatives in water
Molecular Diversity ( IF 3.9 ) Pub Date : 2021-08-19 , DOI: 10.1007/s11030-021-10294-4
Xiaopeng Yang ₁ , Chunmei Li _{1,

2} , Furen Zhang ₁ , Chenze Qi ₁

Affiliation

A strategy for catalyst-free domino reaction of 4-aminopyridin-2(1H)-ones, arylglyoxal hydrates and different 1,3-dicarbonyl compounds in water has been established. The mild and efficient procedure afforded pyrrolo[3,2-c]pyridine derivatives with 76–94% yields after simple crystallization. The present procedure shows promising characteristics, such as readily available starting materials, the use of water as reaction media, simple and efficient one-pot operation, and avoiding the need for any hazardous or expensive catalysts.

Graphic abstract

中文翻译：

在水中合成 3-取代的 4-氧代-4,5-二氢-1H-吡咯并[3,2-c]吡啶衍生物的有效多米诺策略

建立了 4-氨基吡啶-2(1 H )-酮、芳基乙二醛水合物和不同的 1,3-二羰基化合物在水中的无催化剂多米诺反应策略。温和而有效的程序在简单结晶后得到了吡咯并[3,2- c ]吡啶衍生物，产率为 76-94%。本方法显示出有希望的特点，例如容易获得的起始材料、使用水作为反应介质、简单有效的一锅法操作，以及避免使用任何危险或昂贵的催化剂。

图形摘要

更新日期：2021-08-20

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