The essential oil extracted from Aniba canelilla (Kunth) Mez, an aromatic plant from the Amazon region, has 1-nitro-2-phenylethane and methyleugenol as major compounds and although presents historical evidence of treating topical disorders its incorporation in a formulation aiming topical administration was yet unexplored. In this sense, nanoemulsion containing essential oil of A. canelilla was produced by high pressure homogenization and characterized in terms of physicochemical parameters, morphology and thermo and photo (UVA and UVC) stabilities. In addition, in vitro antichemotactic activity was evaluated to the essential oil, isolated compounds and loaded nanoemulsion. The nanoemulsion showed nanometric droplet size with spherical shape, adequate size dispersion and negative charge. The nanoemulsion successfully protected the main compounds of A. canelilla essential oil from thermal degradation and volatilization, also protecting or delaying degradation against UVA and UVC light. The essential oil of A. canelilla, 1-nitro-2-phenylethane, methyleugenol and the nanoemulsion containing A. canelilla essential oil presented antichemotactic activity with reduction of polymorphonuclear neutrophils migration in the range of 24.1–100 %, suggesting an anti-inflammatory potential for these substances, mainly for the loaded nanoemulsion. These promising results revealed that the nanoemulsification of A. canelilla essential oil brought benefits as it maintained stability with an improvement of antichemotactic activity, suggesting it is an interesting strategy for topical delivery of 1-nitro-2-phenylethane and methyleugenol to treat inflamed skin.

从来自亚马逊地区的芳香植物Aniba canelilla (Kunth) Mez 中提取的精油以1-硝基-2-苯基乙烷和甲基丁香酚为主要化合物，虽然提供了治疗局部疾病的历史证据，但将其纳入旨在局部给药的制剂中尚未开发。从这个意义上说，含有小茴香精油的纳米乳液是通过高压均质生产的，并在物理化学参数、形态以及热和光（UVA 和 UVC）稳定性方面进行了表征。此外，体外评估了精油、分离的化合物和负载的纳米乳剂的抗趋化活性。纳米乳液显示具有球形形状的纳米液滴尺寸、足够的尺寸分散和负电荷。纳米乳液成功地保护了小油桐精油的主要化合物免于热降解和挥发，还保护或延迟了对 UVA 和 UVC 光的降解。精油A. canelilla，1-硝基-2-苯基乙烷，甲基丁香酚和含纳米乳剂A. canelilla精油具有抗趋化活性，多形核中性粒细胞迁移减少 24.1-100%，表明这些物质具有抗炎潜力，主要用于负载的纳米乳剂。这些有希望的结果表明，小油菜精油的纳米乳化带来了好处，因为它保持了稳定性并提高了抗趋化活性，这表明它是局部递送 1-硝基-2-苯基乙烷和甲基丁香酚治疗发炎皮肤的有趣策略。