Agrochemical fungicidal leads have been prepared from photochemically derived 1-aminonorbornane building blocks. The unique 1-aminonorbornane core is generated via direct excitation of a Schiff base precursor, leveraging the N-centered radical character of the excited state species to facilitate a series of radical reactions that construct the norbornane core. This process requires no exogenous reagents, only solvent and photons; thus, it represents an exceptionally simple and efficient means of generating the key building blocks. These (hetero)arene-fused 1-aminonorbornanes are unprecedented in both the agrochemical and pharmaceutical discovery literature; therefore, photochemical advances have provided the unique opportunity to explore the functional utility of novel chemical space. Toward this end, the 1-aminonorbornanes were used to generate next-generation succinate dehydrogenase inhibitors. In vitro fungicidal activity is demonstrated against three fungal plant pathogens affecting field crops, specifically: Fusarium graminearum, Sclerotinia sclerotiorum, and Macrophomina phaseolina. The in vitro performance against F. graminearum was shown to translate into a greenhouse setting. The discovery of in planta fungicidal activity illustrates the interdisciplinary value available via photochemical innovation.

农用化学杀菌剂先导物是由光化学衍生的 1-氨基降冰片烷结构单元制备而成。独特的 1-氨基降冰片烷核心是通过席夫碱前体的直接激发生成的，利用激发态物质的N中心自由基特征来促进构建降冰片烷核心的一系列自由基反应。该过程不需要外源试剂，只需要溶剂和光子；因此，它代表了一种极其简单且有效的生成关键构建块的方法。这些（杂）芳烃稠合的 1-氨基降冰片烷在农业化学和药物发现文献中都是前所未有的；因此，光化学的进步为探索新型化学空间的功能提供了独特的机会。为此，1-氨基降冰片烷被用来生成下一代琥珀酸脱氢酶抑制剂。针对影响大田作物的三种真菌植物病原体，特别是：禾谷镰刀菌、核盘菌和菜豆大病菌，证明了其体外杀菌活性。体外对抗禾谷镰刀菌的性能被证明可以转化为温室环境。植物杀菌活性的发现说明了光化学创新所具有的跨学科价值。