组胺受体在癌症进展中的病理生理作用：作为潜在分子靶点的意义和前景,Biomolecules

当前位置： X-MOL 学术 › Biomolecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

组胺受体在癌症进展中的病理生理作用：作为潜在分子靶点的意义和前景
Biomolecules ( IF 4.8 ) Pub Date : 2021-08-18 , DOI: 10.3390/biom11081232
Phuong Linh Nguyen ₁ , Jungsook Cho ₁

Affiliation

在许多不同类型的肿瘤细胞和肿瘤微环境中的细胞中发现了高水平的组胺和组胺受体 (HRs)，包括 H1R~H4R，表明它们参与了肿瘤进展。本综述总结了证明组胺及其同源受体在癌症生物学中的病理生理作用的最新证据。我们还讨论了选择性 HR 配体的新治疗方法及其在癌症治疗中的潜在预后价值。简而言之，组胺通过与不同 HR 的相互作用与癌症的发展、生长和转移密切相关。它还调节免疫细胞向肿瘤部位的浸润，发挥免疫调节功能。此外，各种 HR 配体的作用，包括 H1R 拮抗剂、H2R 拮抗剂和 H4R 激动剂，描述了许多不同癌症类型的肿瘤进展。有趣的是，HR 亚型的表达水平可以作为几种癌症的预后生物标志物。总之，HRs 是癌症治疗的有希望的靶点，HR 配体可以单独或与常规疗法结合提供新的治疗潜力。然而，由于组胺和 HRs 在癌症生物学中的病理生理作用的复杂性，在将 HR 配体引入临床环境之前，有必要进行进一步的研究。

"点击查看英文标题和摘要"

Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets

High levels of histamine and histamine receptors (HRs), including H1R~H4R, are found in many different types of tumor cells and cells in the tumor microenvironment, suggesting their involvement in tumor progression. This review summarizes the latest evidence demonstrating the pathophysiological roles of histamine and its cognate receptors in cancer biology. We also discuss the novel therapeutic approaches of selective HR ligands and their potential prognostic values in cancer treatment. Briefly, histamine is highly implicated in cancer development, growth, and metastasis through interactions with distinct HRs. It also regulates the infiltration of immune cells into the tumor sites, exerting an immunomodulatory function. Moreover, the effects of various HR ligands, including H1R antagonists, H2R antagonists, and H4R agonists, on tumor progression in many different cancer types are described. Interestingly, the expression levels of HR subtypes may serve as prognostic biomarkers in several cancers. Taken together, HRs are promising targets for cancer treatment, and HR ligands may offer novel therapeutic potential, alone or in combination with conventional therapy. However, due to the complexity of the pathophysiological roles of histamine and HRs in cancer biology, further studies are warranted before HR ligands can be introduced into clinical settings.

更新日期：2021-08-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文