Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement,Organic Letters

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Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement
Organic Letters ( IF 4.9 ) Pub Date : 2021-08-18 , DOI: 10.1021/acs.orglett.1c02390
Ling Li ₁ , Shiqi Zhang ₂ , Xiongfei Deng ₂ , Guangxun Li ₂ , Zhuo Tang ₂ , Gang Zhao ₁

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α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

中文翻译：

基于Heyns重排的一锅串联反应制备α-亚氨基酮及其应用

α-亚氨基酮是制备 α-氨基酮和 α-氨基醇的有用构件。然而，很少有人看到它的准备工作。在此，已开发出一种无金属且操作简单的策略来生成具有高区域选择性的 α-亚氨基酮。同时，该方法允许通过一锅级联反应制备具有高区域选择性和非对映选择性的各种N,O-缩酮。

更新日期：2021-09-03

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