Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3,Journal of Fluorine Chemistry

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Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2021-08-17 , DOI: 10.1016/j.jfluchem.2021.109878
Jongkonporn Phetcharawetch ₁ , Nolan M. Betterley ₁ , Vichai Reutrakul ₁ , Darunee Soorukram ₁ , Pawaret Leowanawat ₁ , Chutima Kuhakarn ₁

Affiliation

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes with silver(I) trifluoromethanethiolate (AgSCF₃) has been developed for the construction of 3-((trifluoromethyl)thio)indoles. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time.

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