探索上转换纳米粒子在化学和生物传感器中的使用：从表面修饰到护理点设备,Nanoscale Advances

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探索上转换纳米粒子在化学和生物传感器中的使用：从表面修饰到护理点设备
Nanoscale Advances ( IF 4.6 ) Pub Date : 2021-07-23 , DOI: 10.1039/d1na00327e
Marylyn S Arai ₁ , Andrea S S de Camargo ₁

Affiliation

上转换纳米粒子（UCNP）因其独特的特性而成为有前途的发光纳米材料，可以克服与传统荧光探针相关的几个问题。尽管 UCNP 已被用于广泛的应用，但最能证明其潜力的可能是传感领域。基于 UCNP 的传感器设计具有高灵敏度和选择性，用于检测和定量从金属离子到生物分子的多种分析物。在这篇综述中，我们深入探讨了 UCNP 在传感系统中的使用，强调了与该主题最相关和最新的研究，并解释了这些平台的构建方式。在深入研究基于 UCNP 的传感平台之前，了解这些纳米粒子的独特特性、它们为何吸引如此多的关注以及 UCNP 与其他探针之间发生的最重要的相互作用非常重要。本文的前两节介绍了这些要点，然后我们探讨了荧光响应的类型、可能的分析物以及 UCNP 与各种材料类型（例如金纳米结构、量子点和染料）的集成。所有主题都得到了对最近报道的传感器的分析的支持，重点是它们的构建方式、材料的相互作用、涉及的合成和功能化机制以及共轭策略。最后，我们探讨了 UCNP 在纸质传感器中的使用，以及这些平台如何为新型护理点设备的开发铺平道路。

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Exploring the use of upconversion nanoparticles in chemical and biological sensors: from surface modifications to point-of-care devices

Upconversion nanoparticles (UCNPs) have emerged as promising luminescent nanomaterials due to their unique features that allow the overcoming of several problems associated with conventional fluorescent probes. Although UCNPs have been used in a broad range of applications, it is probably in the field of sensing where they best evidence their potential. UCNP-based sensors have been designed with high sensitivity and selectivity, for detection and quantification of multiple analytes ranging from metal ions to biomolecules. In this review, we deeply explore the use of UCNPs in sensing systems emphasizing the most relevant and recent studies on the topic and explaining how these platforms are constructed. Before diving into UCNP-based sensing platforms it is important to understand the unique characteristics of these nanoparticles, why they are attracting so much attention, and the most significant interactions occurring between UCNPs and additional probes. These points are covered over the first two sections of the article and then we explore the types of fluorescent responses, the possible analytes, and the UCNPs’ integration with various material types such as gold nanostructures, quantum dots and dyes. All the topics are supported by analysis of recently reported sensors, focusing on how they are built, the materials’ interactions, the involved synthesis and functionalization mechanisms, and the conjugation strategies. Finally, we explore the use of UCNPs in paper-based sensors and how these platforms are paving the way for the development of new point-of-care devices.

更新日期：2021-08-15

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