Trifluoroethylthio group (SCH₂CF₃) is a key functionality in several pharmaceutical and agrochemical compounds, the methods for the installation of the 2,2,2-trifluoroethylthio group are sought after. Herein, we report a copper-catalyzed trifluoroethylthiolation reaction of S-(2,2,2-trifluoroethyl) benzenesulfonothioates and phenylboronic acids at room temperature. The reaction achieved the insertion of trifluoroethylthio moiety to efficiently obtain various substituted aryl 2,2,2-trifluoroethyl thioethers in good yields. Mechanistic investigation indicates the trifluoroethylthiolation radical is involved in the catalytic circle. Moreover, trifluoroethylthiolated clofibrate was synthesized in a particular fashion.

三氟乙硫基 (SCH ₂ CF ₃ ) 是几种药物和农用化学品中的关键官能团，安装 2,2,2-三氟乙硫基的方法受到追捧。在此，我们报告了铜催化的 S-(2,2,2-三氟乙基) 苯硫代苯磺酸盐和苯硼酸在室温下的三氟乙基硫醇化反应。该反应实现了三氟乙硫基的插入，以良好的收率有效地获得了各种取代的芳基2,2,2-三氟乙基硫醚。机理研究表明三氟乙基硫醇化自由基参与了催化循环。此外，以特定方式合成了三氟乙基硫醇化氯贝特。