由酶逻辑系统控制的生物燃料电池,Journal of the American Chemical Society

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由酶逻辑系统控制的生物燃料电池
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2009-01-21 , DOI: 10.1021/ja8076704
Liron Amir ₁ , Tsz Kin Tam ₁ , Marcos Pita ₁ , Michael M. Meijler ₁ , Lital Alfonta ₁ , Evgeny Katz ₁

Affiliation

已经开发出一种基于酶的生物燃料电池，其具有可调节 pH 值的氧电极，由处理原位生化输入信号的酶逻辑运算控制。两个布尔逻辑门 (AND/OR) 由酶系统组装而成，用于处理生化信号并将它们逻辑地转换为溶液的 pH 变化。生物燃料电池中使用的阴极用聚合物刷改性，该聚合物刷功能化了 Os 复合氧化还原物质，作为中继单元，以介导导电载体和可溶性漆酶生物催化氧还原之间的电子传输。修饰电极的电化学活性可以通过改变溶液的 pH 值来切换。电极在 pH > 5.5 时电化学静音，并在 pH < 4.5 时被激活用于生物电催化氧还原。通过在系统中作为逻辑开关运行的外部酶系统，使用非活动状态和活动状态之间的急剧转变来控制电极活性。酶逻辑系统根据对应于 AND/OR 布尔逻辑的生化信号的适当组合来降低 pH 值。然后激活可调节 pH 值的电极以进行氧还原，并开启整个生物燃料电池。生物燃料电池也被另一个生化信号关闭，该信号将 pH 值重置为原始中性值。目前的生物燃料电池是未来可植入生物燃料电池的第一个原型，由复杂的生化反应控制，以符合生理需求的合乎逻辑的方式按需提供电力。

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Biofuel Cell Controlled by Enzyme Logic Systems

An enzyme-based biofuel cell with a pH-switchable oxygen electrode, controlled by enzyme logic operations processing in situ biochemical input signals, has been developed. Two Boolean logic gates (AND/OR) were assembled from enzyme systems to process biochemical signals and to convert them logically into pH-changes of the solution. The cathode used in the biofuel cell was modified with a polymer-brush functionalized with Os-complex redox species operating as relay units to mediate electron transport between the conductive support and soluble laccase biocatalyzing oxygen reduction. The electrochemical activity of the modified electrode was switchable by alteration of the solution pH value. The electrode was electrochemically mute at pH > 5.5, and it was activated for the bioelectrocatalytic oxygen reduction at pH < 4.5. The sharp transition between the inactive and active states was used to control the electrode activity by external enzymatic systems operating as logic switches in the system. The enzyme logic systems were decreasing the pH value upon appropriate combinations of the biochemical signals corresponding to the AND/OR Boolean logic. Then the pH-switchable electrode was activated for the oxygen reduction, and the entire biofuel cell was switched ON. The biofuel cell was also switched OFF by another biochemical signal which resets the pH value to the original neutral value. The present biofuel cell is the first prototype of a future implantable biofuel cell controlled by complex biochemical reactions to deliver power on-demand responding in a logical way to the physiological needs.

更新日期：2009-01-21

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