A sensitive colorimetric chiral recognition for thiol-containing amino acids based on NIR plasmonic MoO3−x nanoparticles,Journal of Materials Chemistry C

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A sensitive colorimetric chiral recognition for thiol-containing amino acids based on NIR plasmonic MoO3−x nanoparticles
Journal of Materials Chemistry C ( IF 5.7 ) Pub Date : 2021-07-29 , DOI: 10.1039/d1tc01399h
Shichuan Zhong _{1,

2} , Changchang Xing _{1,

2} , An Cao _{1,

2} , Pan Zeng _{1,

2} , Weiping Cai ₁ , Yue Li ₁

Affiliation

Colorimetric chiral recognition has attracted much attention due to its advantages of facile operation and quick response compared with conventional methods. However, its applicability and sensitivity are remaining challenges. Herein, we develop a universal, high-throughput and sensitive colorimetric chiral recognition and sensing method for discriminating chiral thiol-containing amino acids via sonication of a mixed solution of MoO₃ nanoparticles and enantiomers. The enantiomeric type could be rapidly recognized using the color discrepancy of the MoO_3−x colloid nanoparticles, due to the different concentrations of oxygen vacancies caused by the different degrees of coordination interaction between the MoO_3−x nanoparticles and the carboxyl groups from the enantiomer, which could be certified by investigation using quasi in situ spectroscopy. The mechanism of different coordination interactions between the MoO_3−x nanoparticles and the enantiomer might be caused by different competitve outcomes between coordination interactions and intermolecular hydrogen bonds on reaction with carboxyl groups due to the different intensities of the intermolecular hydrogen bonds of the chiral enantiomers. Moreover, the colorimetric sensing system based on modified MoO_3−x nanoparticles exhibited a detection limit for L-cysteine of 43 nM, which is one order of magnitude lower than current colorimetric probes. This work provides a new inorganic nanoparticle system for universal and high-throughput colorimetric chiral recognition and sensing, and gives insight into the formation mechanism of plasmonic MoO_3−x nanoparticles.

中文翻译：

基于 NIR 等离子体 MoO3−x 纳米粒子的含硫醇氨基酸的灵敏比色手性识别

比色手性识别由于与传统方法相比具有操作简便、响应速度快等优点而备受关注。然而，其适用性和敏感性仍然是挑战。在此，我们开发了一种通用、高通量和灵敏的比色手性识别和传感方法，通过对 MoO ₃纳米颗粒和对映异构体的混合溶液进行超声处理来区分含手性硫醇的氨基酸。由于 MoO _3-_x之间不同程度的配位相互作用导致不同浓度的氧空位，因此可以使用 MoO _{3- x}胶体纳米粒子的颜色差异快速识别对映体类型纳米粒子和对映异构体的羧基，可以通过使用准原位光谱的研究来证明。MoO _{3- x}纳米粒子与对映体之间不同配位相互作用的机制可能是由于手性对映体的分子间氢键强度不同导致配位相互作用和分子间氢键与羧基反应的不同竞争结果引起的。此外，基于改性 MoO _{3− x}纳米颗粒的比色传感系统对L-43 nM 的半胱氨酸，比目前的比色探针低一个数量级。这项工作为通用和高通量比色手性识别和传感提供了一种新的无机纳米粒子系统，并深入了解了等离子体 MoO _{3- x}纳米粒子的形成机制。

更新日期：2021-08-13

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