Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1β) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1β which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1β suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1β.

中文翻译：

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植物源性天然产物靶向白细胞介素-β：治疗动脉粥样硬化性心血管疾病的意义

炎症是动脉粥样硬化中形成粥样斑块的主要因素。白细胞介素 1 β (IL-1β) 是一种在内皮细胞和常驻白细胞中发现的炎症介质。Canakinumab 是一种针对 IL-1β 的选择性单克隆抗体，可减轻炎症并同时引发致命感染和败血症。来自药用植物、草药和功能性食品的天然产品如今被广泛使用。实验和临床试验证据支持一些天然产物如姜黄素、白藜芦醇和槲皮素对 IL-1β 抑制具有潜在影响。在这篇综述中，我们试图记录使用药用植物和植物性天然产物通过抑制 IL-1β 来治疗动脉粥样硬化及其相关疾病的发现。