The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure–activity relationship of this series of compounds are discussed.

中文翻译：

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发现新型基于噻吩并[2,3- d ]嘧啶-4-基zone的Cyclin D1-CDK4抑制剂：合成，生物学评估和结构-活性关系

描述了噻吩并[2,3 - d ]嘧啶-4-基的新类似物的合成和评价。2- Pyrdinecarboxaldehyde [6 - （叔丁基）噻吩并[2,3- d ]嘧啶-4-基]腙衍生物已被鉴定为细胞周期蛋白依赖性激酶4（CDK4）抑制剂。讨论了该系列化合物的效价，选择性分布以及结构-活性关系。