This communication describes a density-based method that uses magnetic levitation for monitoring solid-supported reactions and for distinguishing differences in chemical composition of polymers. The method is simple, rapid, and inexpensive and is similar to thin-layer chromatography (TLC; for solution-phase chemistry) in its potential for monitoring reactions in solid-phase chemistry. The technique involves levitating a sample of beads (taken from a reaction mixture) in a cuvette containing a paramagnetic solution (e.g., GdCl(3) dissolved in H(2)O) positioned between two NdFeB magnets. The vertical position at which the beads levitate corresponds to the density of the beads and correlates with the progress of a chemical reaction on a solid support. The method is particularly useful for monitoring the kinetics of reactions occurring on polymer beads.

中文翻译：

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使用磁悬浮区分聚合物化学成分的原子级差异，并监测固体载体上的化学反应

该通讯描述了一种基于密度的方法，该方法使用磁悬浮来监测固载反应并区分聚合物化学成分的差异。该方法简单、快速且价格低廉，在监测固相化学反应的潜力方面类似于薄层色谱法（TLC；用于溶液相化学）。该技术涉及将珠子样品（取自反应混合物）悬浮在含有顺磁性溶液（例如，溶解在 H(2)O 中的 GdCl(3)）位于两个 NdFeB 磁铁之间的比色皿中。珠子悬浮的垂直位置对应于珠子的密度，并与固体支持物上的化学反应进程相关。