Topical drug therapy is one of the most effective approaches in third-degree burn wound treatments. To optimize and enhance drug permeation through burn eschar, we need to characterize this barrier, most importantly, its affinity to drugs; the subject of this investigation.

Hansen Solubility Parameters (HSP), as polarity and affinity scale, were measured here for human third-degree burn eschar through uptake studies using 19 solvents at 25 °C and 32 °C and two hydration levels by gravimetric method combined with thermal analysis and Karl Fischer titration. HSP parameters of dispersion (δ_D), bipolar (δ_P), and hydrogen bonding (δ_H) were calculated by HSPiP software.

Results showed δ_D, δ_P, and δ_H of 17.0, 12.5, 14.6 and 16.8, 12.4, 14.4 at 25 and 32 °C respectively for normally-hydrated samples. Full hydration increased HSP values to 17.2, 12.9, 15.3 (25 °C) and 17.1, 12.8, 15.1 (32 °C). Good correlations between solvents uptakes and HSP values were observed for all parameters; higher for δ_P. Increased temperature decreased them with more changes in δ_H. Relative Energy Differences (RED) were calculated and shown to be a good parameter for predicting drug-eschar affinity.

The obtained information is useful for drug selection and carrier design in drug delivery through burn eschar.

局部药物治疗是三度烧伤创面治疗最有效的方法之一。为了优化和增强药物通过烧伤焦痂的渗透，我们需要表征这一屏障，最重要的是，它对药物的亲和力；本次调查的对象。

汉森溶解度参数 (HSP)，作为极性和亲和标度，通过使用 25 °C 和 32 °C 下的 19 种溶剂和两个水合水平的重量分析结合热分析和 Karl 的吸收研究测量人类三度烧伤焦痂费歇尔滴定法。HSP 参数的色散 ( δ _D )、双极 ( δ _P ) 和氢键 ( δ _H ) 由 HSPiP 软件计算。

结果显示，正常水合样品在 25 和 32 °C 时的δ _D、δ _P和δ _H分别为 17.0、12.5、14.6 和 16.8、12.4、14.4。完全水合作用将 HSP 值提高到 17.2、12.9、15.3 (25 °C) 和 17.1、12.8、15.1 (32 °C)。所有参数均观察到溶剂吸收和 HSP 值之间的良好相关性；δ _P更高。随着δ _H的更多变化，温度升高会降低它们。计算了相对能量差异 (RED)，并证明它是预测药物-焦痂亲和力的良好参数。

获得的信息可用于通过烧伤焦痂给药的药物选择和载体设计。