丙泊酚复合七氟醚麻醉在分期肝切除肝脱离门静脉结扎术中的应用,Experimental and Therapeutic Medicine

当前位置： X-MOL 学术 › Exp. Ther. Med. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

丙泊酚复合七氟醚麻醉在分期肝切除肝脱离门静脉结扎术中的应用
Experimental and Therapeutic Medicine ( IF 2.4 ) Pub Date : 2021-06-30 , DOI: 10.3892/etm.2021.10353
Fei Xu ₁ , Hongbo Jiang ₂ , Meishan Jin ₃ , Qihua Peng ₄

Affiliation

本研究的目的是探讨丙泊酚联合七氟醚麻醉在分期肝切除术（ALPPS）联合肝分区和门静脉结扎术中的应用。对 40 例接受 ALPPS 的肝癌患者进行回顾性分析。该研究包括21例（对照组）和19例（观察组）分别接受丙泊酚麻醉和丙泊酚联合七氟醚麻醉的患者。记录肝功能指标、血常规参数和凝血功能以及认知功能（简易精神状态检查）的变化。两组患者一、二期手术后总胆红素、直接胆红素水平及丙氨酸氨基转移酶（ALT）水平也较一期手术前升高（P<0.05），ALT水平与二期手术前相比，二期手术后两组的显着降低（P<0.05）。一、二期手术后AST水平分别低于一、二期手术前（P<0.05）。二期手术后白细胞计数明显低于二期手术前（P<0.05）。一期手术后血浆纤维蛋白原（FIB）水平高于一期手术前（P<0.05）。两组患者二期手术后凝血酶原时间较二期手术前升高（P<0.05），而 FIB 水平较低（P<0.05），国际标准化比值为无显着差异（P>0.05）。一、二期手术前的认知减退程度，根据简易精神状态检查评分，与一、二期手术后不同（P<0.05）。综上所述，丙泊酚联合七氟醚在 ALPPS 中具有较好的应用价值。一、二期手术前的认知减退程度，根据简易精神状态检查评分，与一、二期手术后不同（P<0.05）。综上所述，丙泊酚联合七氟醚在 ALPPS 中具有较好的应用价值。一、二期手术前的认知减退程度，根据简易精神状态检查评分，与一、二期手术后不同（P<0.05）。综上所述，丙泊酚联合七氟醚在 ALPPS 中具有较好的应用价值。

"点击查看英文标题和摘要"

Application of propofol combined with sevoflurane anesthesia in staged hepatectomy liver detachment and portal vein ligation.

The aim of the present study was to investigate the application of propofol combined with sevoflurane anesthesia in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). A retrospective analysis of 40 patients with liver cancer who underwent ALPPS was performed. The study included 21 (control group) and 19 (observation group) patients who were administered propofol anesthesia and propofol in combination with sevoflurane anesthesia, respectively. Changes in liver function indicators, routine blood parameters and blood coagulation function, as well as cognitive function (mini-mental state examination) were recorded. The total bilirubin and direct bilirubin levels and the alanine aminotransferase (ALT) level after the first- and second-stage operation in the two groups was also higher than that prior to the first-stage operation (P<0.05), and the ALT level was significantly lower in the two groups after the second-stage operation compared with that prior to the second-stage operation (P<0.05). The AST level after the first- and second-stage operation was lower than that prior to the first- and second-stage operation, respectively (P<0.05). The white blood cell count after the second-stage operation was significantly lower compared with that prior to the second-stage operation (P<0.05). The plasma fibrinogen (FIB) level was higher after the first-stage operation compared with that prior to the first-stage operation (P<0.05). The prothrombin time in the two groups of patients was higher after the second-stage operation compared with that prior to the second-stage operation (P<0.05), whereas the FIB level was lower (P<0.05) and the international normalized ratio was not significantly different (P>0.05). The degree of cognitive decline prior to the first/second-stage operation, according to mini-mental state examination scores, was different from that after the first/second-stage operation (P<0.05). In conclusion, propofol combined with sevoflurane has a good application value in ALPPS.

更新日期：2021-06-30

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南