海藻酸钠/聚（γ-谷氨酸）微球快速止血的安全性和有效性分析,ACS Applied Bio Materials

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海藻酸钠/聚（γ-谷氨酸）微球快速止血的安全性和有效性分析
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-07-30 , DOI: 10.1021/acsabm.1c00671
Yun Wang ₁ , Pei Wang ₁ , Haoran Ji ₂ , Guangyu Ji ₂ , Mingsong Wang ₂ , Xiansong Wang _{1,

2}

Affiliation

大多数可预防的创伤后死亡与出血有关，并且发生在受伤后的早期。及时止血治疗对于减少失血和提高生存率至关重要。在各种治疗方法中，最经济有效的是使用止血剂。粉状止血剂可用于任何形状或深度的伤口，致密性高，积聚效果好。在此，我们选择了天然亲水聚合物聚（γ-谷氨酸）（γ-PGA）与海藻酸钠（SA）形成复合止血微球，具有良好的生物相容性、吸水性和粘度。使用傅里叶变换红外光谱和扫描电子显微镜确定止血微球的形态和结构。整体安全性、溶血性、热原性、并检查了皮内刺激试验。还测量了微球使用期间止血压力和止血时间之间的关系。采用肝、脾、股动脉出血模型分析止血效果。复合微球在体内具有良好的耐受性，在动物实验中表现出比微孔多糖粉末化合物更好的止血效果。研究结果表明，SA/γ-PGA微球是一种止血效果好、安全性高、临床应用潜力巨大的材料。复合微球在体内具有良好的耐受性，在动物实验中表现出比微孔多糖粉末化合物更好的止血效果。研究结果表明，SA/γ-PGA微球是一种止血效果好、安全性高、临床应用潜力巨大的材料。复合微球在体内具有良好的耐受性，在动物实验中表现出比微孔多糖粉末化合物更好的止血效果。研究结果表明，SA/γ-PGA微球是一种止血效果好、安全性高、临床应用潜力巨大的材料。

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Analysis of Safety and Effectiveness of Sodium Alginate/Poly(γ-glutamic acid) Microspheres for Rapid Hemostasis

Most preventable deaths after trauma are related to hemorrhage and occur early after injury. Timely hemostatic treatment is essential to minimize blood loss and improve survival. Among the various treatment methods, the most economical and effective is to use a hemostatic agent. A powdered hemostatic agent can be used for wounds of any shape or depth with high compactness and excellent accumulation effect. Herein, we chose the natural, hydrophilic polymer poly(γ-glutamic acid) (γ-PGA) to form composite hemostatic microspheres with sodium alginate (SA), which show good biocompatibility, water absorptivity, and viscosity. The morphology and structure of the hemostatic microspheres were determined using Fourier transform infrared spectroscopy and scanning electron microscopy. The overall safety, hemolysis, pyrogenic, and intradermal irritation tests were examined. The relationship between hemostatic pressure and hemostatic time during microsphere use was also measured. The hemostatic effect was analyzed with a liver, spleen, and femoral artery bleeding model. The composite microspheres were well tolerated in vivo and exhibited better hemostatic effects in animal experiments than a microporous polysaccharide powder compound. Research results showed that SA/γ-PGA microspheres are materials with good hemostatic effect, high safety, and great potential in clinical applications.

更新日期：2021-08-16

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