Four cyclic octapeptides, squamins C–F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie.

从Annona globiflora Schltdl的种子中分离出四种环状八肽squamins C-F 。这些化合物与之前报道的 squamins A 和 B 共享部分氨基酸序列 -Pro-Met(O)-Tyr-Gly-Thr-。它们的结构是使用 NMR 光谱技术和量子力学计算 (QM-NMR) 确定的)、ESI-HRMS 数据和修改版的 Marfey 色谱方法。所有化合物均显示出对 DU-145（人前列腺癌）和 HeLa（人宫颈癌）细胞系的细胞毒活性。显然，A. globiflora是生物活性分子的重要来源，可以促进这种被低估物种的可持续利用。