Xanthan-Fe3O4 Nanoparticle Composite Hydrogels for Non-Invasive Magnetic Resonance Imaging and Magnetically Assisted Drug Delivery,ACS Applied Nano Materials

当前位置： X-MOL 学术 › ACS Appl. Nano Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Xanthan-Fe3O4 Nanoparticle Composite Hydrogels for Non-Invasive Magnetic Resonance Imaging and Magnetically Assisted Drug Delivery
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-07-26 , DOI: 10.1021/acsanm.1c00932
Marta Ribeiro ₁ , Meriem Boudoukhani ₂ , Efres Belmonte-Reche ₁ , Nuria Genicio ₁ , Sanna Sillankorva ₁ , Juan Gallo ₁ , Carlos Rodríguez-Abreu ₃ , Nadji Moulai-Mostefa _{2,

4} , Manuel Bañobre-López ₁

Affiliation

Implantable long-acting delivery systems able to minimize off-target side effects and locally provide non-invasive imaging reporting are of utmost importance to offer a precise treatment of internal diseases and accurate assessment of disease progression, such as in local infections and tumor relapse following surgery, among other diseases. Here, a biocompatible xanthan gum/Fe₃O₄-based drug-loaded magnetic nanoparticle composite hydrogel with suitable rheological properties and theranostic performance was designed. The ultra-high efficacy of the chemically modified polysaccharide matrix to simultaneously encapsulate hydrophilic drugs and magnetic iron oxide nanoparticles rendered the final hydrogel magnetically responsive to enable thermally induced controlled drug delivery by magnetic hyperthermia as well as non-invasive monitoring by magnetic resonance imaging (MRI). In addition to an enhanced activity of the drug-loaded hydrogel compared to the free drug, results showed that the application of an alternating magnetic field efficiently stimulated a 3-fold faster release of the encapsulated drug compared to passive conditions, whereas a concentration-dependent shortening of the water protons’ relaxation time at a clinical field of 3 T confirmed this magnetic hydrogel as a T₂-MRI contrast enhancer. Altogether, these properties open a novel dimension for the application of these versatile magnetic nanoparticle composite hydrogels, from traditional topical uses to more internal surgery interventions in dentistry, oncology, or wound healing of critical skin damage and infections.

中文翻译：

黄原胶-Fe3O4 纳米颗粒复合水凝胶用于非侵入性磁共振成像和磁辅助给药

植入式长效递送系统能够最大限度地减少脱靶副作用并在局部提供非侵入性成像报告对于提供内部疾病的精确治疗和疾病进展的准确评估至关重要，例如局部感染和肿瘤复发手术等疾病。在这里，生物相容性黄原胶/Fe ₃ O ₄设计了具有合适流变特性和治疗诊断性能的载药磁性纳米颗粒复合水凝胶。化学修饰的多糖基质同时包封亲水性药物和磁性氧化铁纳米粒子的超高功效使最终的水凝胶具有磁响应性，从而能够通过磁热疗和磁共振成像（MRI）进行无创监测）。除了与游离药物相比载药水凝胶的活性增强外，结果表明，与被动条件相比，交变磁场的应用有效地刺激了包封药物的释放速度提高了 3 倍，T ₂ -MRI 对比增强剂。总而言之，这些特性为这些多功能磁性纳米颗粒复合水凝胶的应用开辟了一个新的维度，从传统的局部使用到牙科、肿瘤学或严重皮肤损伤和感染的伤口愈合中更多的内部手术干预。

更新日期：2021-08-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南