A Honeycomb-Like Bismuth/Manganese Oxide Nanoparticle with Mutual Reinforcement of Internal and External Response for Triple-Negative Breast Cancer Targeted Therapy,Advanced Healthcare Materials

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A Honeycomb-Like Bismuth/Manganese Oxide Nanoparticle with Mutual Reinforcement of Internal and External Response for Triple-Negative Breast Cancer Targeted Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-07-23 , DOI: 10.1002/adhm.202100518
Xingyi Xu ₁ , Rongyuan Zhang ₂ , Xianfeng Yang ₁ , Yao Lu ₃ , Zhongmin Yang ₁ , Mingying Peng ₁ , Zhijun Ma ₁ , Ju Jiao ₄ , Lihua Li ₁

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Triple-negative breast cancer (TNBC) exhibits aggressive behavior and high levels of metastasis owing to its complex heterogeneous structure and lack of specific receptors. Here, tumor cell membrane (CM)-coated bismuth/manganese oxide nanoparticles (NPs) with high indocyanine green (ICG) payload up to 50.6 wt% (mBMNI NPs) for targeted TNBC therapy are constructed. The extra-high drug load Bi@Bi₂O₃@MnO_x NPs (honey-comb like structure) are formed by Kirkendall effect and electrostatic attraction. After modified with CM, they can home into tumor sites precisely, where they respond to internal overexpressed glutathione (GSH), releasing Mn²⁺ for chemodynamic therapy (CDT) with GSH depletion, while H₂O₂ degrades into O₂ enabling relief of tumor hypoxia. In response to external near-infrared irradiation, mBMNI NPs intelligently generate vigorous heat and single oxygen (¹O₂) for photothermal therapy (PTT) and photodynamic therapy (PDT) owing to high load. Importantly, O₂ production and GSH consumption during the internal response reinforce external PDT, while the heat generated through PTT during the external response promotes internal CDT. The honeycomb-like structure with high ICG load and mutual reinforcement between internal and external response results in excellent therapeutic effects against TNBC.

中文翻译：

蜂窝状铋/锰氧化物纳米颗粒具有内外反应的相互增强作用，用于三阴性乳腺癌靶向治疗

三阴性乳腺癌（TNBC）由于其复杂的异质结构和缺乏特异性受体而表现出侵袭性行为和高水平转移。在这里，构建了具有高达 50.6 wt% 的高吲哚菁绿（ICG）有效载荷（mBMNI NPs）的肿瘤细胞膜（CM）包覆的铋/氧化锰纳米颗粒（NPs），用于靶向 TNBC 治疗。超高载药量Bi@Bi ₂ O ₃ @MnO _x NPs（蜂窝状结构）是由柯肯德尔效应和静电引力形成的。用 CM 修饰后，它们可以精确定位到肿瘤部位，在那里它们对内部过度表达的谷胱甘肽 (GSH) 作出反应，释放 Mn ²⁺用于 GSH 耗竭的化学动力学治疗 (CDT)，而 H ₂ O₂降解为O ₂从而缓解肿瘤缺氧。响应于外部近红外辐射，由于高负荷，mBMNI NPs 智能地产生强烈的热量和单氧 ( ¹ O ₂ ) 用于光热疗法 (PTT) 和光动力疗法 (PDT)。重要的是，内部反应期间O _{2 的}产生和 GSH 消耗加强了外部 PDT，而外部反应期间通过 PTT 产生的热量促进了内部 CDT。具有高ICG负载和内外反应相互增强的蜂窝状结构对TNBC具有优异的治疗效果。

更新日期：2021-09-22

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