探讨冠心病严重程度与MHR、PHR、NHR、IL-25炎症因子的关系。,Medical Journal of the Islamic Republic of Iran

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探讨冠心病严重程度与MHR、PHR、NHR、IL-25炎症因子的关系。
Medical Journal of the Islamic Republic of Iran Pub Date : 2021-07-01 , DOI: 10.47176/mjiri.35.85
Hamed Manoochehri _{1,

2} , Reza Gheitasi _{2,

3} , Mona Pourjafar _{1,

2} , Razieh Amini ₁ , Amirhossein Yazdi ₄

Affiliation

背景：冠状动脉疾病（CAD）是最常见的死亡原因，主要由动脉粥样硬化引起。由于炎症在动脉粥样硬化过程中的作用，本研究将冠状动脉疾病的严重程度与炎症因子单核细胞与HDL-C比值（MHR）、血小板与HDL-C比值（PHR）的关系)、中性粒细胞与 HDL-C 的比率 (NHR) 和 IL-25 进行了研究。方法：在这项横断面研究中，研究了在哈马丹 Farshchian 心脏中心接受血管造影的 64 名确诊为冠状动脉疾病的患者。对于每位患者，从他们的血液和血清样本中测量单核细胞、中性粒细胞、血小板、HDL-C 和 IL-25 的计数。此外，人口统计信息，如年龄、性别、糖尿病、吸烟和高血压病史，使用清单收集。使用频率、百分比、平均值和标准偏差来描述数据。使用独立 t 检验、Mann-Whitney、Wilcoxon 和 Spearman 秩相关检验以及 SPSS 25.0 版 SPSS Inc) 的多元线性回归进行统计分析。P <.05 被认为是显着的。结果：本研究结果显示IL-25和MHR指数与冠心病和Gensini评分有显着相关性（P˂.001）。PHR 指数与冠状动脉疾病有关。此外，定性变量，如高血压病史、吸烟史和性别，与冠状动脉疾病的严重程度有显着相关性（P <.05）。结论：在检查的炎症标志物中，IL-25 和 MHR 是评估冠状动脉疾病严重程度的更强标志物。简单且可用的 IL-25 和 MHR 测量连同常见的风险因素和血脂特征，可能能够预测治疗中心的血管闭塞量，作为血管造影的替代方法，以及筛查易患心血管疾病的高危患者。

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Investigating the relationship between the severity of coronary artery disease and inflammatory factors of MHR, PHR, NHR, and IL-25.

Background: Coronary artery disease (CAD), as a most common cause of death, is mainly caused by atherosclerosis. Due to the role of inflammation in the process of atherosclerosis, in the present study, the relationship between the severity of coronary artery disease and inflammatory factors of monocyte to HDL-C ratio (MHR), platelet-to-HDL-C ratio (PHR), neutrophil to HDL-C ratio (NHR), and IL-25 was investigated. Methods: In this cross-sectional study, 64 patients with diagnosis of coronary artery disease who were undergoing angiography in Farshchian heart center in Hamadan were studied. For each patient, the count of monocytes, neutrophils, platelet, and HDL-C, and IL-25 were measured from their blood and serum samples. Also, demographic information, such as age, gender, diabetes, smoking, and history of hypertension, was collected using a checklist. Data were described using frequency, percent, mean, and standard deviation. Statistical analysis was performed using independent t test, Mann-Whitney, Wilcoxon, and Spearman rank correlation tests, and multiple linear regression by SPSS version 25.0 SPSS Inc). P <.05 was considered as significant. Results: The results of this study showed that IL-25 and MHR index has a significant correlation with coronary artery disease and Gensini score (P ˂.001). The PHR index was associated with coronary artery disease. Also, qualitative variables, such as history of hypertension, history of smoking, and gender, have a significant association with the severity of coronary artery disease (P <.05). Conclusion: Among the inflammatory markers examined, IL-25 and MHR are stronger markers for assessing the severity of coronary artery disease. Simple and available IL-25 and MHR measurements may be able to, along with common risk factors and lipid profiles, predict the amount of vascular occlusion in treatment centers as an alternative of angiography as well as screening high risk patients prone to cardiovascular disease.

更新日期：2021-07-01

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