Electrochemical Radical δ-H Sulfonylation Reaction for the Synthesis of 4-((Aryl,Arylsul fonyl)methylene)-2,5-Cyclohexadiene Derivatives,The Journal of Organic Chemistry

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Electrochemical Radical δ-H Sulfonylation Reaction for the Synthesis of 4-((Aryl,Arylsul fonyl)methylene)-2,5-Cyclohexadiene Derivatives
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-07-22 , DOI: 10.1021/acs.joc.1c01213
Lei Dai ₁ , Qiuyu Yu ₁ , Jinghang Zhang ₁ , Fan Wu ₁ , Chang Wang ₁ , Jinpeng Zhang ₂ , Liangce Rong ₁

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A novel and efficient electrochemical radical δ-H sulfonylation reaction of para-quinone methides (p-QMs) and sodium sulfinates has been achieved under common laboratory conditions. In this strategy, a new C(sp²)–S bond was constructed for the synthesis of 4-((aryl,arylsulfonyl)methylene)-2,5-cyclohexadiene derivatives with a broad substrate scope, good functional group tolerance, and mild conditions. Further studies showed that the reaction had an excellent regional selectivity.

中文翻译：

用于合成 4-((Aryl,Arylsul fonyl)methylene)-2,5-Cyclo己二烯衍生物的电化学自由基 δ-H 磺酰化反应

在普通实验室条件下，实现了对醌甲基化物 ( p- QMs) 和亚磺酸钠的新型高效电化学自由基 δ-H 磺酰化反应。在该策略中，构建了一个新的 C(sp ² )-S 键用于合成 4-((芳基，芳基磺酰基)亚甲基)-2,5- 环己二烯衍生物，具有广泛的底物范围、良好的官能团耐受性和温和的性质。状况。进一步的研究表明该反应具有良好的区域选择性。

更新日期：2021-08-07

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