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Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2021-09-30 , DOI: 10.2174/0929866528666210622145710
Anubhab Laha 1 , Rajib Bandopadhyay 1 , Anindya Sundar Panja 2
Affiliation  

Background: The incidence of allergy has been increasing at an alarming rate over the last few decades.

Objective: Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens.

Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed.

Results: Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia).

Conclusion: Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.



中文翻译:

不同过敏原的结构系统发育可能揭示共同的表位足迹

背景:在过去的几十年里,过敏的发生率一直在以惊人的速度增加。

目的:我们目前的研究旨在找出不同蛋白质过敏原中存在的结构同源基序。

方法:检索各种花粉、真菌、细菌和食物过敏原的大量蛋白质序列及其相应结构,并分析序列和结构同一性。

结果:序列内和序列间以及它们对蛋白质过敏原的结构分析表明,它们之间不存在显着的关系。在来自真菌、被子植物和动物(鸟类和哺乳动物)的不同过敏原组中观察到一些,但不是可忽略的高度结构相似性。

结论:我们对 36 种不同过敏原的计算机研究表明,无论它们的序列如何,它们之间存在显着的结构相似性。

更新日期:2021-09-30
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