Clays have been used in various health care products, including drug delivery systems. Advanced formulations have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of clays, such as high adsorption, high surface area and high ion exchange capacities, provide an ideal system for the delivery of poorly water-soluble drugs. Currently, there is still limited information on the classification and discussion of clay-based formulations for poorly water-soluble drugs. This review aims to describe efficient delivery systems that use clay as the main excipient in formulations. More details regarding the strategies of using clays in formulations as well as fabrication methods will be discussed. Moreover, combinations with other excipients in hybrid formulations will also be mentioned and the efficacy of these systems will be evaluated. The recent studies on claybased formulations for poorly water-soluble drugs provide fundamental approaches and prospects to be applied in drug development.

粘土已用于各种保健产品，包括药物输送系统。已经研究了先进的配方以充分利用粘土或粘土基材料。粘土的显着特性，如高吸附性、高表面积和高离子交换能力，为水溶性差的药物的输送提供了理想的系统。目前，关于难溶性药物的粘土基制剂的分类和讨论的信息仍然有限。本综述旨在描述在配方中使用粘土作为主要赋形剂的有效递送系统。将讨论有关在配方中使用粘土的策略以及制造方法的更多细节。而且，还将提到在混合制剂中与其他赋形剂的组合，并将评估这些系统的功效。最近对用于难溶性药物的粘土基制剂的研究为药物开发提供了基本的途径和前景。