Bamboo-Like Nanozyme Based on Nitrogen-Doped Carbon Nanotubes Encapsulating Cobalt Nanoparticles for Wound Antibacterial Applications,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bamboo-Like Nanozyme Based on Nitrogen-Doped Carbon Nanotubes Encapsulating Cobalt Nanoparticles for Wound Antibacterial Applications
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-07-16 , DOI: 10.1002/adfm.202105198
Shaoying He ₁ , Junqin Huang ₁ , Qiang Zhang ₂ , Wan Zhao ₁ , Zhiai Xu ₁ , Wen Zhang ₃

Affiliation

In this paper, an artificial nanozyme with efficient oxidase-mimicking activity is developed to investigate antibacterial performance. The bamboo-like nitrogen-doped carbon nanotubes encapsulating cobalt nanoparticles (N-CNTs@Co) are synthesized by pyrolysis of cobalt cyanide cobalt at high temperature. It is found that the oxidase-mimicking activity of N-CNTs@Co is higher than that of iron-centered nanomaterials synthesized by pyrolysis of prussian blue under the same conditions, confirming that the oxidase-mimicking activity is not only related to the active center, but also closely related to its morphology. In addition, the oxidase-mimicking activity of N-CNTs@Co is 12.1 times higher than that of the most reported CeO₂. N-CNTs@Co can catalyze oxygen to produce a large number of reactive oxygen species (ROS) under acidic conditions, resulting in a favorable antibacterial effect against two representative bacteria, Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli). Because the bacterial membrane is damaged by the attack of ROS, the DNA is degraded, eventually causing the bacteria to die. Antibacterial experiments last for 20 days, nevertheless, S. aureus and E. coli do not develop resistance to N-CNTs@Co. The experiments of wound healing in vivo further confirm the high antibacterial efficiency of N-CNTs@Co.

中文翻译：

基于氮掺杂碳纳米管包覆钴纳米颗粒的竹状纳米酶用于伤口抗菌应用

在本文中，开发了一种具有高效氧化酶模拟活性的人工纳米酶来研究抗菌性能。通过高温热解氰化钴钴合成了包裹钴纳米颗粒的竹状氮掺杂碳纳米管（N-CNTs@Co）。发现N-CNTs@Co的氧化酶模拟活性高于普鲁士蓝在相同条件下热解合成的铁中心纳米材料，证实氧化酶模拟活性不仅与活性中心有关，但也与其形态密切相关。此外，N-CNTs@Co 的氧化酶模拟活性是报道最多的 CeO _{2 的}12.1 倍. N-CNTs@Co在酸性条件下可催化氧气产生大量活性氧（ROS），对革兰氏阳性（金黄色葡萄球菌）和革兰氏阴性（大肠杆菌）两种代表性细菌具有良好的抗菌作用. 因为细菌膜被ROS的攻击破坏，DNA被降解，最终导致细菌死亡。抗菌实验持续 20 天，然而，金黄色葡萄球菌和大肠杆菌并未对 N-CNTs@Co 产生抗性。体内伤口愈合实验进一步证实了N-CNTs@Co的高抗菌效率。

更新日期：2021-07-16

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南