Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or Kochia scoparia) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Herein, we demonstrated that Momordin Ic could inhibit HaCaT cell proliferation and enhance cell apoptosis. In the meantime, Momordin Ic alters Wnt/β-catenin pathway activation by affecting β-catenin nuclear distribution. The Wnt/β-catenin signaling activator LiCl partially reversed the effects of Momordin Ic on HaCaT phenotypes and the Wnt/β-catenin pathway factors. Altogether, we demonstrate the inhibitory effects of Momordin Ic, one of the major saponin constituents of Fructus Kochiae, on HaCaT cell proliferation and Momordin Ic-induced alteration within the Wnt/β-catenin pathway. Momordin Ic might act on HaCaT cells by modulating the Wnt/β-catenin pathway.

中文翻译：

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地肤子皂苷苦瓜素 Ic 通过 Wnt/β-Catenin 通路调节 HaCaT 细胞增殖和凋亡

银屑病是一种慢性、复发性、免疫炎症性疾病。长期以来，中医 (TCM) 被认为是银屑病患者的可靠替代疗法。据报道，地肤子（或地肤子）及其主要皂苷苦瓜素可预防炎症。在此，我们证明了Momordin Ic 可以抑制HaCaT 细胞增殖并增强细胞凋亡。同时，Momordin Ic通过影响β -catenin 核分布来改变 Wnt/ β -catenin 通路的激活。Wnt/ β -catenin 信号激活剂 LiCl 部分逆转了木瓜素 Ic 对 HaCaT 表型和 Wnt/ β 的影响-连环蛋白通路因子。总之，我们证明了地肤子的主要皂苷成分之一苦瓜素对 HaCaT 细胞增殖和苦瓜素 Ic 诱导的 Wnt/ β-连环蛋白通路改变的抑制作用。Momordin Ic 可能通过调节 Wnt/ β -catenin 通路作用于 HaCaT 细胞。