Atractylenolide III 通过调节体外和体内人结直肠癌 HCT-116 细胞中的 Bax/Bcl-2 信号通路诱导细胞凋亡。,Anti-Cancer Drugs

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Atractylenolide III 通过调节体外和体内人结直肠癌 HCT-116 细胞中的 Bax/Bcl-2 信号通路诱导细胞凋亡。
Anti-Cancer Drugs ( IF 1.8 ) Pub Date : 2021-07-12 , DOI: 10.1097/cad.0000000000001136
Dan Zhang _{1,

2} , Xiaofang Li _{1,

3} , Daqiang Song ₃ , Siwei Chen ₂ , Zhuo Zhang ₁ , Shousong Cao ₁ , Minghua Liu ₁

Affiliation

白术是白术的干燥根，常用作中药 (TCM)。白术内酯III是白术的主要成分，具有显着的抗炎、抗癌作用。然而，白术内酯III对结肠癌生长抑制和细胞凋亡诱导的作用仍不清楚。结果表明，白术内酯III在体外以浓度依赖性方式显着抑制HCT-116细胞的生长并诱导细胞凋亡。机理研究进一步表明，白术内酯III可通过促进促凋亡相关基因/蛋白Bax、caspase-9和caspase-3的表达，抑制抗凋亡相关基因/蛋白Bcl-2的表达来调节Bax/Bcl-2凋亡信号通路。在 HCT-116 细胞中。此外，白术内酯III还通过上调HCT-116中Bax、cleaved caspase-3和p53的表达，下调Bcl-2的表达，诱导细胞凋亡，显着抑制HCT-116裸鼠移植瘤的肿瘤生长。体内肿瘤组织。这些研究可能为理解白术内酯III的抗癌作用提供科学依据。因此，白术内酯III可能有潜力开发为一种有前景的新型抗癌药物，用于临床治疗结直肠癌。

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Atractylenolide III induces apoptosis by regulating the Bax/Bcl-2 signaling pathway in human colorectal cancer HCT-116 Cells in vitro and in vivo.

Atractylodes is the dry root of atractylodes macrocephala koidz and has been commonly used as a traditional Chinese medicine (TCM). Atractylenolide III, a main component of atractylodes, has displayed significant effects on anti-inflammation and anticancer. However, the effects of atractylenolide III on growth inhibition and apoptosis induction in colon cancer remain unclear. The results showed that atractylenolide III significantly inhibited the cell growth and induce cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro. Mechanistic studies further showed that atractylenolide III could regulate the Bax/Bcl-2 apoptotic signaling pathway through promoting the expression of proapoptotic related gene/proteins Bax, caspase-9 and caspase-3 but inhibiting the expression of antiapoptotic related gene/protein Bcl-2 in HCT-116 cells. Furthermore, atractylenolide III also significantly inhibited the tumor growth of HCT-116 tumor xenografts bearing in nude mice through inducing apoptosis by upregulation of the expressions of Bax, cleaved caspase-3 and p53 but downregulation of the expressions of Bcl-2 in HCT-116 tumor tissues in vivo. The studies may provide the scientific rationale for the understanding of the anticancer effect of atractylenolide III. Therefore, atractylenolide III may have the potential to be developed as a promising novel anticancer agent for the treatment of colorectal cancer clinically.

更新日期：2021-07-17

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