<br>用于化学动力学治疗的新型纳米复合材料（Cu-MOF/GOD@HA）的构建,Nanomaterials

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用于化学动力学治疗的新型纳米复合材料（Cu-MOF/GOD@HA）的构建
Nanomaterials ( IF 4.4 ) Pub Date : 2021-07-16 , DOI: 10.3390/nano11071843
Ya-Nan Hao ₁ , Cong-Cong Qu ₁ , Yang Shu ₁ , Jian-Hua Wang ₁ , Wei Chen _{2,

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Affiliation

新兴的化学动力学疗法（CDT）近年来受到广泛关注。然而，由于肿瘤中H ₂ O ₂的限制，CDT的效率受到影响。在本研究中，我们设计并合成了一种新型核壳纳米结构，铜金属有机框架（Cu-MOF）/葡萄糖氧化酶（GOD）@透明质酸（HA）（Cu-MOF/），以提高CDT功效通过增加 H ₂ O ₂浓度和癌细胞靶向。在此设计中，Cu-MOF 充当 CDT 剂和 GOD 载体。 Cu-MOF 中的 Cu(II) 在 GSH 耗尽的情况下被 GSH 还原为 Cu(I)，从而获得 Cu(I)-MOF。 GSH的消耗增强了肿瘤中H ₂ O ₂的浓度，从而提高了CDT的效率。所得的Cu(I)-MOF催化H ₂ O ₂产生用于CDT的羟基自由基(·OH)。 GOD可以催化葡萄糖(Glu)提供H ₂ O ₂以增强CDT。 HA作为靶向分子，提高Cu-MOF/[email protected]对肿瘤细胞的靶向能力。此外，负载GOD并涂覆HA后，Cu-MOF/[email protected]中Cu(I)的比例较Cu-MOF中Cu(I)的比例有所增加。这种现象可能会缩短从 Cu-MOF 到 Cu(I)-MOF 的反应时间。体外细胞和体内动物研究证明了 Cu-MOF/[email protected] 中 GOD 和 HA 效应导致的 CDT 增强。查看全文

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Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy

The emerging chemodynamic therapy (CDT) has received an extensive attention in recent years. However, the efficiency of CDT is influenced due to the limitation of H₂O₂ in tumor. In this study, we designed and synthesized a novel core-shell nanostructure, Cu-metal organic framework (Cu-MOF)/glucose oxidase (GOD)@hyaluronic acid (HA) (Cu-MOF/) for the purpose of improving CDT efficacy by increasing H₂O₂ concentration and cancer cell targeting. In this design, Cu-MOF act as a CDT agent and GOD carrier. Cu(II) in Cu-MOF are reduced to Cu(I) by GSH to obtain Cu(I)-MOF while GSH is depleted. The depletion of GSH reinforces the concentration of H₂O₂ in tumor to improve the efficiency of CDT. The resultant Cu(I)-MOF catalyze H₂O₂ to generate hydroxyl radicals (·OH) for CDT. GOD can catalyze glucose (Glu) to supply H₂O₂ for CDT enhancement. HA act as a targeting molecule to improve the targeting ability of Cu-MOF/[email protected] to the tumor cells. In addition, after loading with GOD and coating with HA, the proportion of Cu(I) in Cu-MOF/[email protected] is increased compared with the proportion of Cu(I) in Cu-MOF. This phenomenon may shorten the reactive time from Cu-MOF to Cu(I)-MOF. The CDT enhancement as a result of GOD and HA effects in Cu-MOF/[email protected] was evidenced by in vitro cell and in vivo animal studies. View Full-Text

更新日期：2021-07-16

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