ZIF-67、ZIF-90和ZIF-8沸石咪唑酯骨架对一些常见药物递送的实验和分子动力学模拟研究,Applied Organometallic Chemistry

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ZIF-67、ZIF-90和ZIF-8沸石咪唑酯骨架对一些常见药物递送的实验和分子动力学模拟研究
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2021-07-14 , DOI: 10.1002/aoc.6377
Xiaodong Sun ₁ , Maryam Keywanlu ₂ , Reza Tayebee ₂

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长期以来，经常使用抗癫痫药。这些日常使用的抗癫痫药物大多是中枢神经系统抑制剂，过度使用会损害呼吸系统。因此，为了达到预期的治疗目标，避免副作用和药物相互作用，使用靶向药物非常重要。在金属有机框架 (MOF) 中，ZIF 纳米颗粒具有多种优势，例如毛细管流动顺畅、药物释放缓慢、循环和防止血浆中药物浓度增加。加巴喷丁、左乙拉西坦、苯妥英钠和丙戊酸盐是治疗癫痫的有效药物。在本研究中，沸石咪唑酯骨架 ZIF-67、ZIF-90 和 ZIF-8 用作上述药物的载体，并对它们的加载过程进行评估。在这些 MOF 中，ZIF-8 的负载值最高。因此，后者 MOF 是通过一种新的简单方法合成的，并通过 X 射线衍射 (XRD)、傅里叶变换红外 (FT-IR)、扫描电子显微镜 (SEM) 和 X 射线光电子能谱 (XPS) 技术进行表征。此外，这些药物的释放是从 ZIF-8 的孔中测量出来的，这些药物的缓慢释放表明该框架可以用作多种抗癫痫药物的合适载体。最后，通过MTT法研究了加巴喷丁-ZIF-8对Hep-G2肝癌细胞的体外细胞毒性。该研究证实，与未处理的细胞相比，MTT 信号显着降低，所以载药ZIF-8可以降低癌细胞的代谢活性。因此，该纳米颗粒可用作递送所研究药物的载体。

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Experimental and molecular dynamics simulation study on the delivery of some common drugs by ZIF-67, ZIF-90, and ZIF-8 zeolitic imidazolate frameworks

Anti-seizures have been frequently used for a long time. Most of these antiepileptic drugs, which are used on a daily basis, are central nervous system depressants, and their excessive use damages the respiratory system. Therefore, in order to achieve the desired therapeutic goals, avoiding side effects and drug interactions, it is very important to use targeted medications. Among the metal–organic frameworks (MOFs), ZIF nanoparticles have several advantages such as smooth capillary flow and the slow release of drugs, circulating and preventing increased drug concentrations in plasma. Gabapentin, levetiracetam, phenytoin, and valproate are effective drugs in the treatment of epilepsy. In this investigation, the zeolitic imidazolate frameworks ZIF-67, ZIF-90, and ZIF-8 are used as carriers for the above drugs, and their loading processes are evaluated. Among these MOFs, the highest loading values are attained in the case of ZIF-8. Therefore, the latter MOF is synthesized via a new simple method and characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) techniques. Also, the release of these drugs was measured from the pores of ZIF-8, and the slow release of these drugs indicated that the framework could be used as a suitable carrier for a wide range of antiepileptic drugs. Finally, the in vitro cytotoxicity of gabapentin-ZIF-8 against Hep-G2 liver cancer cells was investigated by MTT assay. This study confirmed a significant decrease in the MTT signal compared with the untreated cells, so the drug-loaded ZIF-8 could reduce the metabolic activity of cancer cells. Therefore, this nanoparticle can be used as a carrier for the delivery of the studied drugs.

更新日期：2021-07-14

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