An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into the carbonitrile via the corresponding amide intermediate. The synthesized pyrrolidine derivative was utilized to prepare DPP-IV inhibitor Vildagliptin.

中文翻译：

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（S）-1-（2-氯乙酰基）吡咯烷-2-腈的合成：二肽基肽酶IV抑制剂的关键中间体。

（S）-1-（2-氯乙酰基）吡咯烷-2-腈的另一种实用合成方法。使L-脯氨酸与氯乙酰氯反应，然后将所得N-酰化产物的羧酸部分通过相应的酰胺中间体转化为腈。合成的吡咯烷衍生物用于制备DPP-IV抑制剂维格列汀。