Abstract A series of novel 5‑bromo‑2-chloropyrimidin-4-amine derivatives (7a‐h and 8a‐e) were synthesized by nucleophilic substitution reaction with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, FT‐IR, 1H NMR and LC‐MS spectral studies. All compounds were evaluated for its in vitro antibacterial and antifungal activities. The Compound N-(5‑bromo‑2‑chloro‑pyrimidin-4-yl)-4-methyl-benzenesulfonamide (7b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains.

中文翻译：

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5-溴-2-氯嘧啶-4-胺衍生物的合成及生物活性

摘要 通过与各种磺酰氯和酰氯的亲核取代反应，合成了一系列新型 5-溴-2-氯嘧啶-4-胺衍生物（7a-h 和 8a-e）。新合成的化合物通过元素分析、FT-IR、1H NMR 和 LC-MS 光谱研究进行表征。评估所有化合物的体外抗菌和抗真菌活性。化合物 N-(5-bromo-2-chloro-pyrimidin-4-yl)-4-methyl-benzosulfonamide (7b) 对测试的致病细菌和真菌菌株表现出显着的抗菌活性。