HFC-43-10mee is a volatile liquid at room temperature and used as a cleaning agent, aerosol, etc. HFC-43-10mee has low acute inhalation toxicity; 4-hour LC₅₀ in rats of approximately 11,000 ppm. The compound was not a skin or eye irritant and was not a skin sensitizer. A cardiac sensitization response was not observed at 5000 ppm. Inhalation exposure resulted in neurotoxicity consisting of tremors, convulsions, jerking, ataxia, abnormal gait, etc. at exposure concentrations of 2000 ppm and above. Within approximately 30 min of exposure the clinical signs appeared and resolved within 1–2 h during exposure; the rats appeared to adapt such that these clinical signs were no longer observed. The neurotoxicity observed was considered an acute response to HFC-43-10mee. In a 90-day study, rats exposed to 2000 ppm resulted in sporadic clinical signs of neurotoxicity. At 3500 ppm, the clinical signs were evident on most exposure days although as the study progressed the apparent incidence declined likely reflecting adaptation. The NOAEL was 500 ppm. Based on the occurrence of the clinical signs in this and other studies, an acute threshold for neurotoxicity was evident at approximately 2000 ppm and above. No developmental or reproductive toxicity were evident at 2000 ppm, although clinical signs of neurotoxicity occurred in maternal or parental rats at 2000 ppm. No effects on offspring were observed. HFC-43-10mee was not genotoxic in vitro or in vivo. Based on the data, the 8-h TWA WEEL value is 225 ppm (2320 mg/m³). The 15-min STEL is 700 ppm (7217 mg/m³).

HFC-43-10mee在常温下为挥发性液体，用作清洁剂、气雾剂等。HFC-43-10mee急性吸入毒性低；4 小时 LC ₅₀在大鼠中约为 11,000 ppm。该化合物对皮肤或眼睛没有刺激性，也不是皮肤致敏剂。在 5000 ppm 下未观察到心脏致敏反应。吸入暴露在 2000 ppm 及以上的暴露浓度下会导致神经毒性，包括震颤、抽搐、抽搐、共济失调、步态异常等。在暴露后大约 30 分钟内，临床症状出现并在暴露期间的 1-2 小时内消退；大鼠似乎适应了，以至于不再观察到这些临床症状。观察到的神经毒性被认为是对 HFC-43-10mee 的急性反应。在一项为期 90 天的研究中，大鼠暴露于 2000 ppm 导致神经毒性的零星临床症状。在 3500 ppm 时，在大多数暴露日，临床症状都很明显，尽管随着研究的进行，表观发生率下降，这可能反映了适应。NOAEL 为 500 ppm。根据该研究和其他研究中临床症状的出现，神经毒性的急性阈值在大约 2000 ppm 及以上是明显的。尽管在 2000 ppm 时母体或亲代大鼠出现神经毒性的临床症状，但在 2000 ppm 时没有明显的发育或生殖毒性。未观察到对后代的影响。HFC-43-10mee 在体外或体内均无遗传毒性。根据数据，8 小时 TWA WEEL 值为 225 ppm (2320 mg/m 尽管在 2000 ppm 时母体或亲代大鼠出现神经毒性的临床症状，但在 2000 ppm 时没有明显的发育或生殖毒性。未观察到对后代的影响。HFC-43-10mee 在体外或体内均无遗传毒性。根据数据，8 小时 TWA WEEL 值为 225 ppm (2320 mg/m 尽管在 2000 ppm 时母体或亲代大鼠出现神经毒性的临床症状，但在 2000 ppm 时没有明显的发育或生殖毒性。未观察到对后代的影响。HFC-43-10mee 在体外或体内均无遗传毒性。根据数据，8 小时 TWA WEEL 值为 225 ppm (2320 mg/m³）。15 分钟 STEL 为 700 ppm (7217 mg/m ³ )。