类弹性蛋白多肽的结构-性质关系：实验和计算研究综述,ACS Biomaterials Science & Engineering

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类弹性蛋白多肽的结构-性质关系：实验和计算研究综述
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-07-12 , DOI: 10.1021/acsbiomaterials.1c00145
Diego López Barreiro ₁ , Inge J Minten ₂ , Jens C Thies ₃ , Cees M J Sagt ₁

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弹性蛋白是一种结构蛋白，具有出色的机械特性（例如弹性和弹性）和生物学相关功能（例如触发细胞粘附或趋化性等反应）。它由其前体弹性蛋白原形成，弹性蛋白原是一种 60-72 kDa 的水溶性温度响应蛋白，在生理温度下凝聚，经历称为较低临界溶解温度 (LCST) 的现象。受这种行为的启发，许多科学家和工程师正在开发重组生产的弹性蛋白生物聚合物，通常称为类弹性蛋白多肽（ELP）。这些ELP通常由具有序列VPGXG的重复基序组成，其对应于原弹性蛋白序列的一小部分的重复，X是除脯氨酸之外的任何氨基酸。ELP 显示出与原弹性蛋白相似的 LCST 和机械性能，这使得它们成为开发弹性和刺激响应性蛋白质材料的有希望的候选者。通过建立 ELP 氨基酸序列与材料宏观特性之间的联系，揭示 ELP 的结构-特性关系可以帮助开发这些材料。在这里，我们回顾了 ELP 和 ELP 材料的结构-性能关系，重点关注 LCST 和机械性能，以及实验和计算研究如何帮助理解它们。通过建立 ELP 氨基酸序列与材料宏观特性之间的联系，揭示 ELP 的结构-特性关系可以帮助开发这些材料。在这里，我们回顾了 ELP 和 ELP 材料的结构-性能关系，重点关注 LCST 和机械性能，以及实验和计算研究如何帮助理解它们。通过建立 ELP 氨基酸序列与材料宏观特性之间的联系，揭示 ELP 的结构-特性关系可以帮助开发这些材料。在这里，我们回顾了 ELP 和 ELP 材料的结构-性能关系，重点关注 LCST 和机械性能，以及实验和计算研究如何帮助理解它们。

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Structure–Property Relationships of Elastin-like Polypeptides: A Review of Experimental and Computational Studies

Elastin is a structural protein with outstanding mechanical properties (e.g., elasticity and resilience) and biologically relevant functions (e.g., triggering responses like cell adhesion or chemotaxis). It is formed from its precursor tropoelastin, a 60–72 kDa water-soluble and temperature-responsive protein that coacervates at physiological temperature, undergoing a phenomenon termed lower critical solution temperature (LCST). Inspired by this behavior, many scientists and engineers are developing recombinantly produced elastin-inspired biopolymers, usually termed elastin-like polypeptides (ELPs). These ELPs are generally comprised of repetitive motifs with the sequence VPGXG, which corresponds to repeats of a small part of the tropoelastin sequence, X being any amino acid except proline. ELPs display LCST and mechanical properties similar to tropoelastin, which renders them promising candidates for the development of elastic and stimuli-responsive protein-based materials. Unveiling the structure–property relationships of ELPs can aid in the development of these materials by establishing the connections between the ELP amino acid sequence and the macroscopic properties of the materials. Here we present a review of the structure–property relationships of ELPs and ELP-based materials, with a focus on LCST and mechanical properties and how experimental and computational studies have aided in their understanding.

更新日期：2021-07-12

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