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Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-07-09 , DOI: 10.1021/acsami.1c09889 Yu Wang 1 , Ye Wu 1 , Linyu Long 2 , Li Yang 2 , Daihua Fu 2 , Cheng Hu 2 , Qingquan Kong 1, 3 , Yunbing Wang 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-07-09 , DOI: 10.1021/acsami.1c09889 Yu Wang 1 , Ye Wu 1 , Linyu Long 2 , Li Yang 2 , Daihua Fu 2 , Cheng Hu 2 , Qingquan Kong 1, 3 , Yunbing Wang 2
Affiliation
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Stimuli-responsive hydrogels possess unique advantages in drug delivery due to their variable performance and status based on the external environment. In the present study, a dual-responsive (pH and reactive oxygen species (ROS)) hydrogel was prepared to realize drug release properties under inflammatory stimulation. By grafting 3-carboxy-phenylboronic acid to the gelatin molecular backbone and cross-linking with poly(vinyl alcohol), we successfully synthesized the inflammation-responsive drug-loaded hydrogels after encapsulation with vancomycin-conjugated silver nanoclusters (VAN-AgNCs) and pH-sensitive micelles loaded with nimesulide (NIM). This novel design not only retained the dynamic functions of hydrogels, such as injectability, self-healing, and remodeling, but also realized sequential and on-demand drug delivery at diabetic-infected wound sites. In this work, we found that the hydrogel exhibited excellent biocompatibility and hemostasis properties owing to the enhanced cell-adhesive property of the gelatin component. The significant antibacterial and anti-inflammatory effect of the hydrogel was demonstrated in an in vitro experiment. Moreover, in the in vivo experiment, the hydrogel was found to play a role in promoting infected wound healing through sequential hemostasis and antibacterial and anti-inflammatory processes. Collectively, this inflammation-responsive hydrogel design containing VAN-AgNCs and NIM-loaded micelles has great potential in the application of chronically infected diabetic wound treatment, as well as in other inflammatory diseases.
中文翻译：
具有序贯止血、抗菌和抗炎作用的炎症响应载药水凝胶，用于治疗慢性感染的糖尿病伤口
刺激响应水凝胶由于其性能和状态随外部环境而变化，在药物递送方面具有独特的优势。在本研究中，制备了一种双响应（pH 和活性氧（ROS））水凝胶，以实现炎症刺激下的药物释放特性。通过将3-羧基苯基硼酸接枝到明胶分子主链上并与聚乙烯醇交联，我们成功合成了万古霉素缀合银纳米簇（VAN-AgNCs）和pH值封装后的炎症响应性载药水凝胶。 -负载尼美舒利（NIM）的敏感胶束。这种新颖的设计不仅保留了水凝胶的动态功能，如可注射性、自愈性和重塑性，而且还实现了糖尿病感染伤口部位的顺序和按需给药。在这项工作中，我们发现由于明胶成分增强的细胞粘附特性，水凝胶表现出优异的生物相容性和止血特性。体外实验证明了水凝胶具有显着的抗菌和抗炎作用。此外，在体内实验中，发现水凝胶通过顺序止血、抗菌和抗炎过程发挥促进感染伤口愈合的作用。总的来说，这种含有 VAN-AgNC 和负载 NIM 的胶束的炎症响应水凝胶设计在慢性感染糖尿病伤口治疗以及其他炎症性疾病的应用中具有巨大的潜力。
更新日期：2021-07-21
中文翻译：
具有序贯止血、抗菌和抗炎作用的炎症响应载药水凝胶，用于治疗慢性感染的糖尿病伤口
刺激响应水凝胶由于其性能和状态随外部环境而变化，在药物递送方面具有独特的优势。在本研究中，制备了一种双响应（pH 和活性氧（ROS））水凝胶，以实现炎症刺激下的药物释放特性。通过将3-羧基苯基硼酸接枝到明胶分子主链上并与聚乙烯醇交联，我们成功合成了万古霉素缀合银纳米簇（VAN-AgNCs）和pH值封装后的炎症响应性载药水凝胶。 -负载尼美舒利（NIM）的敏感胶束。这种新颖的设计不仅保留了水凝胶的动态功能，如可注射性、自愈性和重塑性，而且还实现了糖尿病感染伤口部位的顺序和按需给药。在这项工作中，我们发现由于明胶成分增强的细胞粘附特性，水凝胶表现出优异的生物相容性和止血特性。体外实验证明了水凝胶具有显着的抗菌和抗炎作用。此外，在体内实验中，发现水凝胶通过顺序止血、抗菌和抗炎过程发挥促进感染伤口愈合的作用。总的来说，这种含有 VAN-AgNC 和负载 NIM 的胶束的炎症响应水凝胶设计在慢性感染糖尿病伤口治疗以及其他炎症性疾病的应用中具有巨大的潜力。
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