Efficient domino strategy for synthesis of 3-substituted 1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one derivatives,Journal of Heterocyclic Chemistry

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Efficient domino strategy for synthesis of 3-substituted 1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-07-08 , DOI: 10.1002/jhet.4339
Huaqian Chen ₁ , Tao Lu ₁ , Minglong Qiao ₁ , Jiawen Hu ₁ , Chunmei Li _{1,

2} , Chenze Qi ₁ , Furen Zhang ₁

Affiliation

A series of 1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one derivatives with 3-(4-hydroxy-2-oxo-2H-pyran-3-yl) groups were synthesized via a one-pot three-component reaction of 4-aminopyridin-2(1H)-ones, 2,2-dihydroxy-1-arylethan-1-ones, and 4-hydroxy-2H-pyran-2-ones in water. This strategy not only provides a valuable tool in the design and synthesis of new hydrogenated pyrrolo[3,2-c]pyridines but also has the advantages of inexpensive starting materials, atom and step economy, environmental friendliness, good to excellent yields, and operational simplicity. A total of 14 examples were examined to show a broad substrate scope and high yields.

中文翻译：

合成3-取代1,5-二氢-4H-吡咯并[3,2-c]pyridin-4-one衍生物的有效多米诺策略

合成了一系列具有3-(4-hydroxy-2-oxo-2 H -pyran-3-yl)基团的1,5-dihydro-4 H - pyrrolo[3,2 - c ]pyridin-4-one衍生物通过 4-aminopyridin-2(1 H )-ones、2,2-dihydroxy-1-arylethan-1-ones 和 4-hydroxy-2 H -pyran-2-ones的一锅三组分反应水。该策略不仅为新型氢化吡咯并[3,2- c ]吡啶的设计和合成提供了一个有价值的工具，而且具有原料廉价、原子和步骤经济、环境友好、产率高到优异、可操作性强等优点。简单。总共检查了 14 个示例以显示广泛的底物范围和高产量。

更新日期：2021-07-08

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